Many modern metabolic diseases, including type 2 diabetes and non-alcoholic fatty liver disease, involve altered or faulty communication between different tissues and/or organs. Several modes and molecules of communication and signaling are involved, including extracellular vesicles, endocrine hormones, cytokines, involving both constitutive tissues and commensal microbiota. For these processes to be identified and characterized in a clinical setting, various disciplines and methods of analysis and diagnosis must be integrated. As an example, the imaging of liver fat and fibrosis could be analyzed along with the characterization of intestinal microbiome activity to understand the role of intestinal dysbiosis in driving fatty liver disease.
The goal of this research topic is to present new advances in the integration of epidemiology and new pathogenic mechanisms that improve our understanding of biological crosstalk within diabetes, non-alcoholic fatty liver disease, and other endocrine disorders settings. Specifically, it will focus on approaches that can be applied in the clinical setting. The implication of tissue crosstalk processes in clinical diagnosis and treatment for these metabolic diseases will also be highlighted. Therefore, researchers in the area of metabolic diseases are welcome to contribute with original research articles, methods, meta-analyses, case-studies, or reviews.
Many modern metabolic diseases, including type 2 diabetes and non-alcoholic fatty liver disease, involve altered or faulty communication between different tissues and/or organs. Several modes and molecules of communication and signaling are involved, including extracellular vesicles, endocrine hormones, cytokines, involving both constitutive tissues and commensal microbiota. For these processes to be identified and characterized in a clinical setting, various disciplines and methods of analysis and diagnosis must be integrated. As an example, the imaging of liver fat and fibrosis could be analyzed along with the characterization of intestinal microbiome activity to understand the role of intestinal dysbiosis in driving fatty liver disease.
The goal of this research topic is to present new advances in the integration of epidemiology and new pathogenic mechanisms that improve our understanding of biological crosstalk within diabetes, non-alcoholic fatty liver disease, and other endocrine disorders settings. Specifically, it will focus on approaches that can be applied in the clinical setting. The implication of tissue crosstalk processes in clinical diagnosis and treatment for these metabolic diseases will also be highlighted. Therefore, researchers in the area of metabolic diseases are welcome to contribute with original research articles, methods, meta-analyses, case-studies, or reviews.