Immune cells were initially recognized as core elements for foreign pathogen clearance in infectious diseases. Nevertheless, increasing evidence has demonstrated that immune cells could play a paramount role, being either pro-inflammatory or anti-inflammation in the pathogenesis of non-infectious diseases such as diabetes, hypertension, non-alcoholic fatty liver disease, and cardiovascular disease.
Cardiovascular disease and cancer are the leading causes of mortality worldwide. Data have consistently shown that different types of TH cells are infiltrated into atherosclerotic plaque where they facilitate inflammation and plaque progression. By contrast, regulatory T cells are critical in the induction and maintenance of immune homeostasis and tolerance. Likewise, the immune response becomes activated in patients with ischemic heart failure where they provoke adverse cardiac remodeling and strengthen cardiomyopathy. On top of that, patients with cardiovascular disease or cancer always have metabolic disorders that further amplify immune responses and accelerate disease progression. After the outbreak of COVID-19, a notion arises that immune cells are mediators of micro- and macrovascular dysfunction and heart failure. It further indicates the central roles of immune cells in these disorders.
The goal of this Research Topic aims to provide a scientific forum for the latest and advanced research for better understanding the nature of immune cells in cardiovascular and metabolic disorders. From the mechanism aspect, the immune cells and their secreted products promote phagocytosis to fight against pathogen infection. Remarkably, they also serve as messengers in organ communication where they elicit an immune response and metabolic homeostasis. The scope of this research topic issue preferentially covers the latest and advanced results on the roles of immune cells in cardiovascular and metabolic orders. Both research articles and reviews are welcome except case reports. In detail, this Research Topic focuses on new updates of the following aspects:
• The role of immune cells in cardiovascular and metabolic disorders
• How immune cells are regulated in cardiovascular and metabolic disorders
Immune cells were initially recognized as core elements for foreign pathogen clearance in infectious diseases. Nevertheless, increasing evidence has demonstrated that immune cells could play a paramount role, being either pro-inflammatory or anti-inflammation in the pathogenesis of non-infectious diseases such as diabetes, hypertension, non-alcoholic fatty liver disease, and cardiovascular disease.
Cardiovascular disease and cancer are the leading causes of mortality worldwide. Data have consistently shown that different types of TH cells are infiltrated into atherosclerotic plaque where they facilitate inflammation and plaque progression. By contrast, regulatory T cells are critical in the induction and maintenance of immune homeostasis and tolerance. Likewise, the immune response becomes activated in patients with ischemic heart failure where they provoke adverse cardiac remodeling and strengthen cardiomyopathy. On top of that, patients with cardiovascular disease or cancer always have metabolic disorders that further amplify immune responses and accelerate disease progression. After the outbreak of COVID-19, a notion arises that immune cells are mediators of micro- and macrovascular dysfunction and heart failure. It further indicates the central roles of immune cells in these disorders.
The goal of this Research Topic aims to provide a scientific forum for the latest and advanced research for better understanding the nature of immune cells in cardiovascular and metabolic disorders. From the mechanism aspect, the immune cells and their secreted products promote phagocytosis to fight against pathogen infection. Remarkably, they also serve as messengers in organ communication where they elicit an immune response and metabolic homeostasis. The scope of this research topic issue preferentially covers the latest and advanced results on the roles of immune cells in cardiovascular and metabolic orders. Both research articles and reviews are welcome except case reports. In detail, this Research Topic focuses on new updates of the following aspects:
• The role of immune cells in cardiovascular and metabolic disorders
• How immune cells are regulated in cardiovascular and metabolic disorders