For 3.5 billion years, bacterial organisms have been evolving on our planet and constantly adapting to their environment. In this time, they have developed phenomenal adaptations to survive, including to promote their survival within a host. Consequently, our health depends on the trillions of bacteria that make up our various microbiomes, but also on pathogenic bacteria. Their epidemiological, socio-economic and politico-historical importance has only been truly appreciated during the last 150 years, for example with the ongoing problem of bacterial multi-resistance, or for the benefits provided by a healthy microbiota. Thus, it is critical to decipher the molecular mechanisms and signalling networks set up by these bacteria to develop new therapies against drug-resistant bacteria or to harness health benefits associated with healthy microbiomes. Over the last 30 years, "omics" approaches have revolutionized our knowledge of the microbiological world by providing new insight into these mechanisms and networks for pathogenic bacteria, host-pathogen relationships and microbiota.
Despite the importance and the huge number of bacterial organisms present on our planet, they are still dramatically underrepresented in the literature. It is now essential to fill this gap in our knowledge, starting with the characterization of human-bacterial interplay in both health and disease. Given the complexity of bacterial systems in both isolated cultures and in communities, omics type research methodologies have provided an unrivalled platform from which to understand them. As such, this special research topic invites submissions showcasing the role of omics in understanding bacterial systems, as well as their complex interplay with humans. These would include the use of genomic, transcriptomic, proteomic, PTM-omics, metabolomic and bioinformatic approaches to: (1) understand bacteria in culture or communities (i.e. microbiomes) in context of their clinical importance; (2) characterize the impact or role of bacteria within human cells, tissues or individuals; and (3) identify the signalling mechanisms (e.g. immune pathways) displayed by the human host in response to infection, colonization or change in microbiome.
This special topic would catalogue the applications of omic technologies that can contribute to significant advancements in our understanding of human-bacterial interplay. Notably, this topic will focus on the diverse impacts displayed by bacteria from model pathogenic organisms to commensal microbiomes, and their role in well-being and disease. This special research topic welcomes manuscripts including but not limited to:
• Using omics to understand bacterial signalling mechanisms, including bacteria-host signalling
• The development of drug resistance in bacteria
• Multi-omics approaches to bacterial biology and signalling
• Using omics to determine the role of the human microbiomes in disease and well-being
We will consider all type of manuscripts (e.g. original research, review).
For 3.5 billion years, bacterial organisms have been evolving on our planet and constantly adapting to their environment. In this time, they have developed phenomenal adaptations to survive, including to promote their survival within a host. Consequently, our health depends on the trillions of bacteria that make up our various microbiomes, but also on pathogenic bacteria. Their epidemiological, socio-economic and politico-historical importance has only been truly appreciated during the last 150 years, for example with the ongoing problem of bacterial multi-resistance, or for the benefits provided by a healthy microbiota. Thus, it is critical to decipher the molecular mechanisms and signalling networks set up by these bacteria to develop new therapies against drug-resistant bacteria or to harness health benefits associated with healthy microbiomes. Over the last 30 years, "omics" approaches have revolutionized our knowledge of the microbiological world by providing new insight into these mechanisms and networks for pathogenic bacteria, host-pathogen relationships and microbiota.
Despite the importance and the huge number of bacterial organisms present on our planet, they are still dramatically underrepresented in the literature. It is now essential to fill this gap in our knowledge, starting with the characterization of human-bacterial interplay in both health and disease. Given the complexity of bacterial systems in both isolated cultures and in communities, omics type research methodologies have provided an unrivalled platform from which to understand them. As such, this special research topic invites submissions showcasing the role of omics in understanding bacterial systems, as well as their complex interplay with humans. These would include the use of genomic, transcriptomic, proteomic, PTM-omics, metabolomic and bioinformatic approaches to: (1) understand bacteria in culture or communities (i.e. microbiomes) in context of their clinical importance; (2) characterize the impact or role of bacteria within human cells, tissues or individuals; and (3) identify the signalling mechanisms (e.g. immune pathways) displayed by the human host in response to infection, colonization or change in microbiome.
This special topic would catalogue the applications of omic technologies that can contribute to significant advancements in our understanding of human-bacterial interplay. Notably, this topic will focus on the diverse impacts displayed by bacteria from model pathogenic organisms to commensal microbiomes, and their role in well-being and disease. This special research topic welcomes manuscripts including but not limited to:
• Using omics to understand bacterial signalling mechanisms, including bacteria-host signalling
• The development of drug resistance in bacteria
• Multi-omics approaches to bacterial biology and signalling
• Using omics to determine the role of the human microbiomes in disease and well-being
We will consider all type of manuscripts (e.g. original research, review).
