About this Research Topic
The cell signaling machinery is a critical component of the immune system that relays information from the receptors to the nucleus where transcription of key immune genes is activated. Host cells have developed signal transduction systems to maintain homeostasis with pathogens. Most cellular processes and cell signaling pathways are tightly regulated by protein phosphorylation in which protein kinases are key protagonists. Pathogens have developed multiple mechanisms to subvert important signal transduction pathways such as the mitogen activated protein kinase (MAPK) and the nuclear factor kB (NF-kB) pathways. Pathogens also secrete effectors that manipulate actin cytoskeleton and its regulators, hijack cell cycle machinery and alter vesicular trafficking.
This research topic focuses on the cellular signaling mechanisms that are essential for host immunity and their subversion by pathogens. The topic will cover largely, but not exclusively, the NF-κB pathway, the MAPK cascade, the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway, the Protein Kinase R (PKR) and the p21-activated kinase (PAK) pathway.
We welcome the submission of Original Research articles and Review articles on the subject, which include activation of host cell kinase pathways in response to infection and their subversion by pathogens (parasites, fungi, bacteria and viruses). We also welcome Hypothesis and Theory articles on experimental evidence and theoretical basis, highlighting what we have learnt about how mammalian hosts developed signaling pathways to control invading pathogens.
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