Research Topic

Etiopathogenesis of Systemic Sclerosis: An Update

  • Submission closed.

About this Research Topic

Systemic Sclerosis (SSc) is a chronic systemic disease characterized by extensive fibrosis of skin and internal organs, microvascular abnormalities, autoimmune phenomena. To date, etiopathogenesis of SSc is still a obscure. Several factors have been shown to play a role in SSc, as autoimmune phenomena, ...

Systemic Sclerosis (SSc) is a chronic systemic disease characterized by extensive fibrosis of skin and internal organs, microvascular abnormalities, autoimmune phenomena. To date, etiopathogenesis of SSc is still a obscure. Several factors have been shown to play a role in SSc, as autoimmune phenomena, environmental (infection, chemical etc) and tumor triggers, genetic background, vascular damage, primary fibroblast alterations. However despite the increasing body of data, generated in vivo and in vitro, SSc still remains an “elusive” disease and no effective therapy for SSc is available. This Research Topic will overview all these issues, trying to address all the recent advances in the field. Therefore, we expect to discuss humoral and cellular immune responses, genetics, experimental in vitro and in vivo models, role of infections, clinical feature, cell and vascular alterations. Briefly, we want to assess the current knowledge about SSc and try to bridge what we know with future directions and new therapeutical approaches.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top