Bacterial infection continues to be a major source of concern in the healthcare sector and is responsible for substantial morbidity and mortality. This scenario is growing more complicated as the population becomes older and more vulnerable to infection as a result of the high number of bacterial isolates that have developed resistance to antibiotics. A biofilm is a survival strategy for bacteria and fungi that allows them to adapt to their living environment, which is particularly important under hostile conditions. Under the protection of biofilm, microbial cells in biofilm build up tolerance and resistance to antibiotics as well as immunological responses, which increases the difficulties in the clinical treatment of biofilm infections. Clinical observations and experimental investigations have clearly shown that antibiotic therapy alone is, in the majority of situations, inadequate to eradicate biofilm infections in the human body. As a result, it has become a very important and urgent need for clinicians to find novel approaches to prevent biofilm formation, in addition to the currently available treatment options.
Therefore, the primary objective of this special issue is to summarize the mechanisms underlying biofilm drug resistance and the most recent advancements or investigations in the prevention of bacterial biofilm formation.
This special issue welcomes submissions for consideration of publication in the form of original research papers, review papers, news, opinions, and editorial commentary.
Bacterial infection continues to be a major source of concern in the healthcare sector and is responsible for substantial morbidity and mortality. This scenario is growing more complicated as the population becomes older and more vulnerable to infection as a result of the high number of bacterial isolates that have developed resistance to antibiotics. A biofilm is a survival strategy for bacteria and fungi that allows them to adapt to their living environment, which is particularly important under hostile conditions. Under the protection of biofilm, microbial cells in biofilm build up tolerance and resistance to antibiotics as well as immunological responses, which increases the difficulties in the clinical treatment of biofilm infections. Clinical observations and experimental investigations have clearly shown that antibiotic therapy alone is, in the majority of situations, inadequate to eradicate biofilm infections in the human body. As a result, it has become a very important and urgent need for clinicians to find novel approaches to prevent biofilm formation, in addition to the currently available treatment options.
Therefore, the primary objective of this special issue is to summarize the mechanisms underlying biofilm drug resistance and the most recent advancements or investigations in the prevention of bacterial biofilm formation.
This special issue welcomes submissions for consideration of publication in the form of original research papers, review papers, news, opinions, and editorial commentary.
