In recent years, the biosynthesis of high-value chemicals and natural products has attracted significant research and industrial attention. The main driving force of the biosynthesis market is the growing interest in pharmaceuticals, food ingredients, agricultural products, bioplastics, and green chemicals. In general, biosynthesis encompasses upstream, midstream and downstream processes, where upstream processes, through dealing with the development of strains as biocatalysts, are considered to be the key step. In fact, microorganisms play the central role in biosynthesis, and the performance of biocatalysts determines the overall viability and acceptability of this technology.
Although significant research efforts have been devoted to strain and bioprocess engineering over the past years to obtain viable technologies for biosynthesis, many of these technologies have not yet been commercially explored because of low competitiveness, as well as low production performance matrices, including titer, yield and productivity. The major existing issues are low stability and low tolerance of the strains to stressors, slow growth rate, unbalanced metabolic pathway, and distribution of carbon flux to unwanted products. With the rapid development of rational, evolutionary and microenvironment engineering strategies, there has been growing interest in pathway modulation, and strain engineering to improve the performance of biocatalysts over their wild counterparts. Likewise, substantial attention has been paid to the midstream step, which mainly involves fermentation and requires proper configuration and simulation for the desired titer, yield and productivity of the target product.
This topic aims to cover the biocatalysts and bioprocess technologies for efficient biosynthesis through metabolic engineering, pathway modulation, and process engineering. We welcome original research articles, study protocols, policy and practice reviews, reviews, brief research reports, case reports, mini reviews and perspectives. Topics of interest for this issue collection include, but are not limited to:
• Biosynthesis of value-added chemicals (e.g., bulk chemicals, platform chemicals, biopolymers, and natural products).
• Model and non-model cell factories used for biosynthesis
• Novel pathways and pathway engineering for biosynthesis.
• Systems metabolic engineering for biosynthesis.
• OMICS-based study for improving the performance of production strain (e.g., genomics, transcriptomics, metabolomics, proteomics, etc.)
• Bioprocess configuration and simulation for biosynthesis.
In recent years, the biosynthesis of high-value chemicals and natural products has attracted significant research and industrial attention. The main driving force of the biosynthesis market is the growing interest in pharmaceuticals, food ingredients, agricultural products, bioplastics, and green chemicals. In general, biosynthesis encompasses upstream, midstream and downstream processes, where upstream processes, through dealing with the development of strains as biocatalysts, are considered to be the key step. In fact, microorganisms play the central role in biosynthesis, and the performance of biocatalysts determines the overall viability and acceptability of this technology.
Although significant research efforts have been devoted to strain and bioprocess engineering over the past years to obtain viable technologies for biosynthesis, many of these technologies have not yet been commercially explored because of low competitiveness, as well as low production performance matrices, including titer, yield and productivity. The major existing issues are low stability and low tolerance of the strains to stressors, slow growth rate, unbalanced metabolic pathway, and distribution of carbon flux to unwanted products. With the rapid development of rational, evolutionary and microenvironment engineering strategies, there has been growing interest in pathway modulation, and strain engineering to improve the performance of biocatalysts over their wild counterparts. Likewise, substantial attention has been paid to the midstream step, which mainly involves fermentation and requires proper configuration and simulation for the desired titer, yield and productivity of the target product.
This topic aims to cover the biocatalysts and bioprocess technologies for efficient biosynthesis through metabolic engineering, pathway modulation, and process engineering. We welcome original research articles, study protocols, policy and practice reviews, reviews, brief research reports, case reports, mini reviews and perspectives. Topics of interest for this issue collection include, but are not limited to:
• Biosynthesis of value-added chemicals (e.g., bulk chemicals, platform chemicals, biopolymers, and natural products).
• Model and non-model cell factories used for biosynthesis
• Novel pathways and pathway engineering for biosynthesis.
• Systems metabolic engineering for biosynthesis.
• OMICS-based study for improving the performance of production strain (e.g., genomics, transcriptomics, metabolomics, proteomics, etc.)
• Bioprocess configuration and simulation for biosynthesis.