The number of children surviving a congenital anomaly has been steadily increasing over the last three decades, thanks to the advances in pediatric cardiology, cardiac surgery and intensive care. It is estimated that nowadays over 85% of these children have been growing into adulthood and continue to do so, and most of the deaths from congenital heart disease occur in adulthood. Tetralogy of Fallot is the most common cyanotic congenital cardiac lesion, and its treatment has improved dramatically over the last three decades, effectively granting survival to all but a few infants with this condition. However, despite the excellent survival afforded by surgical and percutaneous interventions, tetralogy of Fallot continues to be a significant burden, requiring surgery in childhood, lifelong follow up and often repeated interventions for multiple sequelae and complications. The mains causes for such complications remain the dysplastic pulmonary valve, the pulmonary vasculature and the restrictive right ventricle, which continue to elude resolutive care. Several aspects of treatment remain problematic and controversial.
This comprehensive review aims at providing the reader with the most recent up-to-date information on tetralogy of Fallot, from its intrauterine development to the long term sequelae of the condition. It aims in particular at addressing some ongoing controversial aspects, such as the ideal surgical strategy to tackle the problem of a dysplastic/hypoplastic pulmonary valve, the management of restrictive physiology and the management of surgical/interventional complications.
In this Research Topic we welcome the following topic areas, encompassing the whole range of manifestation of the defect from fetus to adulthood:
Fetal diagnosis and counselling, potential and current foetal interventions
Genetic and environmental factors, and impact on phenotype
Latest developments in embryology of Tetralogy of Fallot
The right ventricle physiology and pathology in animal models
Controversies in treatment of Tetralogy of Fallot
Palliation vs Repair as first approach
TAP vs Aggressive RVOT preservation
Early vs Late Reintervention
Surgical vs Percutaneous Reinterventions
Advanced echocardiographic imaging
Pre and Post Operative Multimodality imaging
Interdisciplinary approach for the care of tetralogy of Fallot patients
PA and MAPCAs : one for large programs only?
Tetralogy of Fallot in 20 years - where are we going?
The number of children surviving a congenital anomaly has been steadily increasing over the last three decades, thanks to the advances in pediatric cardiology, cardiac surgery and intensive care. It is estimated that nowadays over 85% of these children have been growing into adulthood and continue to do so, and most of the deaths from congenital heart disease occur in adulthood. Tetralogy of Fallot is the most common cyanotic congenital cardiac lesion, and its treatment has improved dramatically over the last three decades, effectively granting survival to all but a few infants with this condition. However, despite the excellent survival afforded by surgical and percutaneous interventions, tetralogy of Fallot continues to be a significant burden, requiring surgery in childhood, lifelong follow up and often repeated interventions for multiple sequelae and complications. The mains causes for such complications remain the dysplastic pulmonary valve, the pulmonary vasculature and the restrictive right ventricle, which continue to elude resolutive care. Several aspects of treatment remain problematic and controversial.
This comprehensive review aims at providing the reader with the most recent up-to-date information on tetralogy of Fallot, from its intrauterine development to the long term sequelae of the condition. It aims in particular at addressing some ongoing controversial aspects, such as the ideal surgical strategy to tackle the problem of a dysplastic/hypoplastic pulmonary valve, the management of restrictive physiology and the management of surgical/interventional complications.
In this Research Topic we welcome the following topic areas, encompassing the whole range of manifestation of the defect from fetus to adulthood:
Fetal diagnosis and counselling, potential and current foetal interventions
Genetic and environmental factors, and impact on phenotype
Latest developments in embryology of Tetralogy of Fallot
The right ventricle physiology and pathology in animal models
Controversies in treatment of Tetralogy of Fallot
Palliation vs Repair as first approach
TAP vs Aggressive RVOT preservation
Early vs Late Reintervention
Surgical vs Percutaneous Reinterventions
Advanced echocardiographic imaging
Pre and Post Operative Multimodality imaging
Interdisciplinary approach for the care of tetralogy of Fallot patients
PA and MAPCAs : one for large programs only?
Tetralogy of Fallot in 20 years - where are we going?
