Research Topic

New Insights into the Pathophysiology and Treatment of Neonatal Hypoxic-ischemic Encephalopathy

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Neonatal hypoxic-ischemic encephalopathy (HIE) remains one of the most important causes of neurodevelopmental impairments in infants. In the last few years, the combined effort of basic scientists and clinical researchers led to the successful implementation of therapeutic hypothermia as the standard ...

Neonatal hypoxic-ischemic encephalopathy (HIE) remains one of the most important causes of neurodevelopmental impairments in infants. In the last few years, the combined effort of basic scientists and clinical researchers led to the successful implementation of therapeutic hypothermia as the standard treatment for HIE. Nevertheless, a large number of children would still benefit from additional therapies. This Research Topic will primarily focus on understanding basic cellular and molecular mechanisms associated with the pathophysiology of HIE and on the search for new therapies for this disease.

We welcome submissions from researchers working with animal models of HIE, as well as those working with clinical populations. Only by combining the knowledge from basic science and preclinical/translational studies with the insights from clinical and population studies, will it be possible to advance our understanding of HIE - a crucial step for the identification of better prognostic and diagnostic markers and for the development of novel treatments for this disease. We are particularly interested in studies that make use of non-invasive in vivo imaging techniques, including bioluminescence, fluorescence, ultrasound, nuclear medicine and magnetic resonance imaging, to assess functional and structural parameters in the brain, such as the progression of the hypoxic-ischemic lesion and its response to different therapies. Thus, we encourage the submission of original research reports, methods articles, reviews and mini reviews, perspectives and hypothesis & theory articles, in the following (but not limited to) topics:

- Mechanisms of cell death and neuroprotection in HIE;
- The role of immune cells and inflammatory mediators in the pathogenesis of HIE and the development of immunomodulatory therapies for HIE;
- Endogenous mechanisms of brain repair and regeneration and its therapeutic implications in HIE;
- Novel therapeutic strategies for HIE, including cell therapies and bioengineering approaches;
- The identification of diagnostic and prognostic biomarkers for HIE;
- High-throughput genome, epigenome, transcriptome and proteome analysis in HIE;
- Use of imaging methods to track cell therapies for HIE;
- Use of imaging methods to evaluate the function and structure of the brain after HIE and their response to treatments.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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