About this Research Topic
One of the aims of metabolomics research is to identify the mechanisms involved in the development and progress of a disease. The significance of prevention, treatment and slowing down the progression of various ophthalmic diseases raises no doubts in the context of reducing health and economic burden and improving the quality of life. Metabolomics has already shown its utility in ophthalmic research, however, the role of small molecules in many eye diseases is not fully elucidated and for others has never been studied. Although plasma and urine are the specimens most commonly studied in biomedical metabolomics research, in case of eye disease more challenging samples, e.g. aqueous or vitreous humor as well as tears, conjunctiva, cornea, retina, etc. can provide more detailed information about the molecular status at the site of the disease. In case of human studies, the specimens from the eye are less readily available and can be obtained in small amounts. However, animal models of ophthalmic diseases are also available.
The aim of this Special Issue is to provide a collection of articles advancing our knowledge of the physiology and pathophysiology of ophthalmic diseases as well as identification of biomarkers using metabolomics approach. Basic research using cellular and animal models, clinical studies, as well as the implications of the findings in the clinical setting are welcome. Analysis of various biospecimens from humans, cell cultures, and animals would give a broader perspective. As aqueous or vitreous humor are less commonly studied samples, which analysis can be challenging from the analytical perspective, methodological studies focusing on the analysis of small molecules in this type of samples would be also appreciated. In case of untargeted metabolomics studies multiplatform approaches may allow the detection of a comprehensive spectrum of metabolites facilitating the indication of novel metabolites and disturbed metabolic pathways.
This Research Topic welcomes Original Research, Methods, Reviews, Mini Reviews, Brief Research Reports focusing on, but not limited to, the following subjects related to ophthalmology and analysis of eye-related samples:
• Clinical metabolomics in the context of eye diseases.
• Application of metabolomics to study animal models of ophthalmic diseases.
• Analytical approaches to study small molecules in the eye-related samples, e.g. aqueous humor, vitreous humor, tears, retina, or cornea.
• Metabolomics studies of tumors and systemic diseases with ophthalmic manifestation.
The aim of this Special Issue is to provide a collection of articles advancing our knowledge of the physiology and pathophysiology of ophthalmic diseases as well as identification of biomarkers using metabolomics approach. Basic research using cellular and animal models, clinical studies, as well as the implications of the findings in the clinical setting are welcome. Analysis of various biospecimens from humans, cell cultures, and animals would give a broader perspective. As aqueous or vitreous humor are less commonly studied samples, which analysis can be challenging from the analytical perspective, methodological studies focusing on the analysis of small molecules in this type of samples would be also appreciated. In case of untargeted metabolomics studies multiplatform approaches may allow the detection of a comprehensive spectrum of metabolites facilitating the indication of novel metabolites and disturbed metabolic pathways.
This Research Topic welcomes Original Research, Methods, Reviews, Mini Reviews, Brief Research Reports focusing on, but not limited to, the following subjects related to ophthalmology and analysis of eye-related samples:
• Clinical metabolomics in the context of eye diseases.
• Application of metabolomics to study animal models of ophthalmic diseases.
• Analytical approaches to study small molecules in the eye-related samples, e.g. aqueous humor, vitreous humor, tears, retina, or cornea.
• Metabolomics studies of tumors and systemic diseases with ophthalmic manifestation.
Keywords: metabolomics, eye, ophthalmology, LC-MS, GC-MS, metabolic fingerprinting, NMR-based metabolomics, analytical chemistry, aqueous humor, vitreous, retina, tear, cornea, lens, conjuctiva, plasma, serum, animal, mouse, chick, guinea pig
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
