Central nervous system (CNS) tumors, including brain and spinal cord tumors cause significant morbidity and mortality across all ages. Management of CNS tumors is challenging for clinicians for various reasons, including complex diagnostic procedures, intricate therapeutic interventions, limited treatment efficacy, incomplete preservation of neurologic function, and lack of tools for treatment planning and prognosis prediction. There are unmet needs for better management of CNS tumors.
Recent advances in understanding molecular underpinnings of CNS tumors have brought about novel targetable molecular alterations. Enhanced knowledge of the tumor immune microenvironment has further driven the development of novel immune-based therapies. Emerging applications of advanced neuroimaging such as radiomics has also facilitated prognosis prediction and treatment planning by integrating patients’ imaging phenotypes, clinical data and molecular profiling. These technological progresses have substantially promoted precision oncology for CNS tumor management.
The standard treatment for most CNS tumors is maximal safe surgical resection, yet therapeutic options also consist of multimodality approaches including radiotherapies, systemic therapies, local therapies, supportive care, and the emerging immunotherapy and targeted therapy. To achieve optimal treatment, it is critical to acquire the knowledge and capability to apply adequate treatment modalities in an interdisciplinary approach, which demands collaboration of experts in diverse disciplines.
In this Research Topic we hope to promote the advances in clinical and translational application of precision oncology for CNS tumor treatment, treatment planning and prognosis prediction. As well as to encourage the updated and innovative application of multimodality approaches for CNS tumor treatment.
We welcome original research and review articles focusing on the following subtopics including but not limited to:
- Clinical and translational application of precision oncology, including targeted therapy, immunotherapy, radiomics, molecular markers, etc., in CNS tumor treatment, treatment planning and prognosis prediction.
- Clinical application of multimodality approaches in CNS tumor treatment to promote minimally invasiveness of surgery, treatment efficacy and neurologic function preservation.
Central nervous system (CNS) tumors, including brain and spinal cord tumors cause significant morbidity and mortality across all ages. Management of CNS tumors is challenging for clinicians for various reasons, including complex diagnostic procedures, intricate therapeutic interventions, limited treatment efficacy, incomplete preservation of neurologic function, and lack of tools for treatment planning and prognosis prediction. There are unmet needs for better management of CNS tumors.
Recent advances in understanding molecular underpinnings of CNS tumors have brought about novel targetable molecular alterations. Enhanced knowledge of the tumor immune microenvironment has further driven the development of novel immune-based therapies. Emerging applications of advanced neuroimaging such as radiomics has also facilitated prognosis prediction and treatment planning by integrating patients’ imaging phenotypes, clinical data and molecular profiling. These technological progresses have substantially promoted precision oncology for CNS tumor management.
The standard treatment for most CNS tumors is maximal safe surgical resection, yet therapeutic options also consist of multimodality approaches including radiotherapies, systemic therapies, local therapies, supportive care, and the emerging immunotherapy and targeted therapy. To achieve optimal treatment, it is critical to acquire the knowledge and capability to apply adequate treatment modalities in an interdisciplinary approach, which demands collaboration of experts in diverse disciplines.
In this Research Topic we hope to promote the advances in clinical and translational application of precision oncology for CNS tumor treatment, treatment planning and prognosis prediction. As well as to encourage the updated and innovative application of multimodality approaches for CNS tumor treatment.
We welcome original research and review articles focusing on the following subtopics including but not limited to:
- Clinical and translational application of precision oncology, including targeted therapy, immunotherapy, radiomics, molecular markers, etc., in CNS tumor treatment, treatment planning and prognosis prediction.
- Clinical application of multimodality approaches in CNS tumor treatment to promote minimally invasiveness of surgery, treatment efficacy and neurologic function preservation.