Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases that is characterized by progressive and severe dementia. In recent years, there have been major advances in the understanding of its pathogenesis and treatment. However, the effective treatment of AD remains elusive. Meanwhile, growing evidence indicates that AD is a multifactorial and complex disorder, and its occurrence and development are influenced by multiple pathogenic processes rather than a single factor. The identification of crosstalk between different mechanisms can provide insights for a novel strategy targeting.
Mechanisms of Alzheimer’s disease pathogenesis have been extensively revealed, such as cholinergic neuron damage, amyloid β (Aβ), Tau, oxidative stress, mitochondrial dysfunction, inflammation, glucose hypometabolism, etc. Researchers realize the interaction between various peripheral tissues and brain tissues, but the role of the crosstalk in cognitive impairments associated with aging, Alzheimer's disease, and related dementias remains unclear.
This Research Topic welcomes contributions, in the form of Original Research, Review, and Opinion, involving pre-clinical (basic science) and clinical research, to explore the crosstalk of different pathogenic mechanisms and/or different tissues in aging and AD-related cognitive impairments. Studies of crosstalk and/or comorbidities between different diseases and AD, investigations under the lens of gender perspective, as well as pharmacological and non-pharmacological interventions to modulate them, are also welcome. Potential topics of interest include but are not limited to the following:
• Crosstalk between Aβ/tau and inflammation/oxidative stress/mitochondrial dysfunction/metabolic dysfunction
• Crosstalk between systemic and CNS inflammation
• Crosstalk between gut and brain in Alzheimer's disease
• Crosstalk between different signaling pathways in Alzheimer's disease
• Crosstalk between diabetes and Alzheimer's disease
• Sex/gender effects on the all mentioned crosstalk above
Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases that is characterized by progressive and severe dementia. In recent years, there have been major advances in the understanding of its pathogenesis and treatment. However, the effective treatment of AD remains elusive. Meanwhile, growing evidence indicates that AD is a multifactorial and complex disorder, and its occurrence and development are influenced by multiple pathogenic processes rather than a single factor. The identification of crosstalk between different mechanisms can provide insights for a novel strategy targeting.
Mechanisms of Alzheimer’s disease pathogenesis have been extensively revealed, such as cholinergic neuron damage, amyloid β (Aβ), Tau, oxidative stress, mitochondrial dysfunction, inflammation, glucose hypometabolism, etc. Researchers realize the interaction between various peripheral tissues and brain tissues, but the role of the crosstalk in cognitive impairments associated with aging, Alzheimer's disease, and related dementias remains unclear.
This Research Topic welcomes contributions, in the form of Original Research, Review, and Opinion, involving pre-clinical (basic science) and clinical research, to explore the crosstalk of different pathogenic mechanisms and/or different tissues in aging and AD-related cognitive impairments. Studies of crosstalk and/or comorbidities between different diseases and AD, investigations under the lens of gender perspective, as well as pharmacological and non-pharmacological interventions to modulate them, are also welcome. Potential topics of interest include but are not limited to the following:
• Crosstalk between Aβ/tau and inflammation/oxidative stress/mitochondrial dysfunction/metabolic dysfunction
• Crosstalk between systemic and CNS inflammation
• Crosstalk between gut and brain in Alzheimer's disease
• Crosstalk between different signaling pathways in Alzheimer's disease
• Crosstalk between diabetes and Alzheimer's disease
• Sex/gender effects on the all mentioned crosstalk above