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Toward an improved understanding of the ionizing radiation (IR) induced DNA damage/response (DDRs) networks in human malignancies

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The treatment of most human malignancies consists of a combination of surgery, radiation, and chemotherapy. Radiation plays a critical role in local control and survival for many of these tumors. Differential ionizing radiation (IR) induced DNA damage response (DDRs) networks are a major component ...

The treatment of most human malignancies consists of a combination of surgery, radiation, and chemotherapy. Radiation plays a critical role in local control and survival for many of these tumors. Differential ionizing radiation (IR) induced DNA damage response (DDRs) networks are a major component determining tumor response as well as acute and late normal tissue toxicities. And additional determinants of tumor radiation resistance have emerged, including differential regulation of signaling cascades, cell cycle regulation, and extracellular interactions. With the advent of delineating molecular subtypes of various human malignancies and our better understanding of IR-induced DDRs, more targeted therapies for human cancers are being proposed, based on ongoing pre-clinical research and early clinical trials. In this Frontiers Research Topic, we propose to create an interactive forum for reporting and discussing these research efforts. We encourage submission of basic, translational and clinical research papers as well as hypothesis and theory articles and reviews.

Keywords: DNA damage, DNA repair, radiation


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