Gut microbiota play a crucial role in development and progression of colorectal cancer. Microbes interact with the intestinal mucosal surfaces directly and regulate host immune systems or tumor microenvironment of carcinoma in situ. Some metabolites of microbes, such as short chain fatty acids, are pivotal factors involved in CD3+/CD8+ cell infiltration, tumor infiltrating T cell differentiation, abundance of tumor associated macrophages, and antigen presentation in tumor. Metabolites can also enter peripheral blood. For example, about 0.5-14.2 μM butyrate derived from gut microbiota entered the circulatory system after being absorbed by colon cells and hepatic metabolism. These metabolites impact on the tumor microenvironment in distal metastasis tumors through the circulatory system. Furthermore, metabolites of microbes also regulate some key proteins in signaling pathways related to chemotherapy resistance. For example, butyrate regulates EGFR which is related to EGFR TKI therapy. Understanding the compositional structures and metabolites of gut microbiota involved in development and chemotherapy resistance of colorectal cancer will provide strategies for developing novel therapies.
This Research Topic particularly focuses on the mechanisms of the influence of gut microbiota, or their metabolites, on chemotherapy resistance of colorectal cancer. Bioinformatics analysis of clinical data about gut microbiota and prognosis of chemotherapy are also welcome.
All study types are welcome, including but not limited to research articles, observational studies, meta-analysis, reviews or case reports/series.
Gut microbiota play a crucial role in development and progression of colorectal cancer. Microbes interact with the intestinal mucosal surfaces directly and regulate host immune systems or tumor microenvironment of carcinoma in situ. Some metabolites of microbes, such as short chain fatty acids, are pivotal factors involved in CD3+/CD8+ cell infiltration, tumor infiltrating T cell differentiation, abundance of tumor associated macrophages, and antigen presentation in tumor. Metabolites can also enter peripheral blood. For example, about 0.5-14.2 μM butyrate derived from gut microbiota entered the circulatory system after being absorbed by colon cells and hepatic metabolism. These metabolites impact on the tumor microenvironment in distal metastasis tumors through the circulatory system. Furthermore, metabolites of microbes also regulate some key proteins in signaling pathways related to chemotherapy resistance. For example, butyrate regulates EGFR which is related to EGFR TKI therapy. Understanding the compositional structures and metabolites of gut microbiota involved in development and chemotherapy resistance of colorectal cancer will provide strategies for developing novel therapies.
This Research Topic particularly focuses on the mechanisms of the influence of gut microbiota, or their metabolites, on chemotherapy resistance of colorectal cancer. Bioinformatics analysis of clinical data about gut microbiota and prognosis of chemotherapy are also welcome.
All study types are welcome, including but not limited to research articles, observational studies, meta-analysis, reviews or case reports/series.