Among the possible biomolecules suitable as anti-cancer drug targets, intracellular proteins are particularly appealing as major oncoproteins like Kras, c-Myc and mutant p-53 belong to this class. However, their intracellular location is a major challenge for drug development and delivery, as most therapeutic active molecules, like antibodies, are too big to penetrate the cell membrane.
The cell membrane is a fluid entity characterized by an enormous complexity of lipids and proteins. Its composition changes according to the environment and between tissue and cell function. In addition, neoplastic cells can be characterized by an abnormal cell membrane lipid composition.
The transfer of molecules across the membrane is finely tuned and the recent success of mRNA vaccines against SAR-CoV-2 has marked a milestone in the development of new molecule-delivery systems.
This Research Topic aims to explore the plasma membrane as the ultimate barrier to intracellular drug delivery and target of intracellular oncoproteins. Furthermore, we aim to explore new molecule-delivery systems and their mechanism of action.
We welcome submission of reviews, original research articles, and perspectives focused on the newest discoveries in drug delivery across the plasma membrane to target intracellular oncoproteins. Manuscripts describing mechanisms of action are particularly welcomed. Topics of interest include, but are not limited to:
- Viral vectors
- Nanodevices and nanoparticles
- Membrane-impermeable drugs delivery
- Nucleic acid delivery
- Cell-penetrating peptides
- Exogenous organelles
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Among the possible biomolecules suitable as anti-cancer drug targets, intracellular proteins are particularly appealing as major oncoproteins like Kras, c-Myc and mutant p-53 belong to this class. However, their intracellular location is a major challenge for drug development and delivery, as most therapeutic active molecules, like antibodies, are too big to penetrate the cell membrane.
The cell membrane is a fluid entity characterized by an enormous complexity of lipids and proteins. Its composition changes according to the environment and between tissue and cell function. In addition, neoplastic cells can be characterized by an abnormal cell membrane lipid composition.
The transfer of molecules across the membrane is finely tuned and the recent success of mRNA vaccines against SAR-CoV-2 has marked a milestone in the development of new molecule-delivery systems.
This Research Topic aims to explore the plasma membrane as the ultimate barrier to intracellular drug delivery and target of intracellular oncoproteins. Furthermore, we aim to explore new molecule-delivery systems and their mechanism of action.
We welcome submission of reviews, original research articles, and perspectives focused on the newest discoveries in drug delivery across the plasma membrane to target intracellular oncoproteins. Manuscripts describing mechanisms of action are particularly welcomed. Topics of interest include, but are not limited to:
- Viral vectors
- Nanodevices and nanoparticles
- Membrane-impermeable drugs delivery
- Nucleic acid delivery
- Cell-penetrating peptides
- Exogenous organelles
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
