About this Research Topic
Accurate molecular assessment of clinically relevant and validated biomarkers is crucial in adminstering the best treatment for advanced stage gynecological cancer patients. In this setting, molecular predictive pathology has acquired a key role in the management of these patients. The efficacy of Poly (ADP-ribose) Polymerase (PARP) inhibitors (PARPi) in patients harboring genomic alterations in breast cancer (BRCA) 1 and 2 genes has already been widely demonstrated and careful attention has been paid to the role of immune-checkpoint inhibitors (ICIs) in patients harboring a high microsatellite instability (MSI-H) status.
In this Research Topic we would like to discuss the methods, findings and prospects of evidence from molecular pathology that will help in the early diagnosis, treatment decision-making and drug resistance prediction in gynecological malignancies. Articles of the Original Research, Review, Mini Review, Opinion and Perspective type will be considered. Potential topics include but are not limited to the following:
1) The role of different BRCA alterations as predictors of response to PARPi;
2) Validated biomarkers associated with immunotherapy outcomes;
3) Validated biomarkers for prediction of drug resistance;
4) Next-generation sequencing and its application in the diagnosis of gynecological malignancies;
5) The role of HRD.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Umberto Malapelle has received personal fees (as consultant and/or speaker bureau) from Boehringer Ingelheim, Roche, MSD, Amgen, Thermo Fisher Scientifics, Eli Lilly, Diaceutics, GSK, Merck and AstraZeneca.
Keywords: ovarian cancer, endometrial cancer, cervical cancer, molecular pathology, targeted therpy, molecular oncology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.