The blood–brain barrier (BBB) dysfunction contributes to Alzheimer’s disease and related cognitive disorders. The BBB is composed of a highly selective semipermeable border formed by capillary endothelial cells, astrocytic end-feet, and pericytes embedded in the basement membrane that prevents solutes in the circulating blood from non-selectively crossing into the brain. The BBB belongs to the glymphatic system and the intramural periarterial drainage pathway, which is involved in clearing interstitial solutes from the brain across the basement membrane to maintain brain homeostasis. The current researchers have enthusiastically been developing visualization systems of BBB dynamics using advanced magnetic resonance imaging and molecular imaging techniques.
The purpose of this research topic is to encourage the proposal of advanced methodologies related to the BBB imaging technique and its application to the BBB related diseases. We hope this research topic will help to better understand our brain around the BBB physiology and pathophysiology.
Sub-themes of this topic include but are not limited to the following:
1) Novel methods that facilitate the progress of BBB imaging techniques.
2) High-resolution and high-field ex vivo or in vivo BBB imaging to better characterize properties of diseased tissues.
3) Potential applications of BBB imaging techniques in Alzheimer’s disease and related disorders.
4) Analysis of BBB functions using advanced imaging techniques in the whole brain or specific brain regions between patients and healthy controls to find biomarkers for neurodegenerative diseases or try to explain their pathogenesis.
5) Applications of BBB imaging in studying pathological processes of brain diseases that contribute to disease classification and early diagnosis.
The blood–brain barrier (BBB) dysfunction contributes to Alzheimer’s disease and related cognitive disorders. The BBB is composed of a highly selective semipermeable border formed by capillary endothelial cells, astrocytic end-feet, and pericytes embedded in the basement membrane that prevents solutes in the circulating blood from non-selectively crossing into the brain. The BBB belongs to the glymphatic system and the intramural periarterial drainage pathway, which is involved in clearing interstitial solutes from the brain across the basement membrane to maintain brain homeostasis. The current researchers have enthusiastically been developing visualization systems of BBB dynamics using advanced magnetic resonance imaging and molecular imaging techniques.
The purpose of this research topic is to encourage the proposal of advanced methodologies related to the BBB imaging technique and its application to the BBB related diseases. We hope this research topic will help to better understand our brain around the BBB physiology and pathophysiology.
Sub-themes of this topic include but are not limited to the following:
1) Novel methods that facilitate the progress of BBB imaging techniques.
2) High-resolution and high-field ex vivo or in vivo BBB imaging to better characterize properties of diseased tissues.
3) Potential applications of BBB imaging techniques in Alzheimer’s disease and related disorders.
4) Analysis of BBB functions using advanced imaging techniques in the whole brain or specific brain regions between patients and healthy controls to find biomarkers for neurodegenerative diseases or try to explain their pathogenesis.
5) Applications of BBB imaging in studying pathological processes of brain diseases that contribute to disease classification and early diagnosis.
