Resistance to chemotherapy, targeted therapy, and immune therapy are the leading causes of cancer treatment failure and death. RNA-binding proteins (RBPs) interact with RNA elements in a dynamic manner, modulating mRNA processing, stability, transport, and translation. RBPs have recently been discovered to regulate the stability and localization of long non-coding RNAs (lncRNAs). RBPs may also bind circular RNAs (circRNAs) and play important roles in circRNA production and degradation. RBPs are often dysregulated in human cancers, and they control the expression and activity of oncogenic and tumor-suppressor proteins, which govern tumor response to different therapies such as chemotherapy, targeted therapy, and immunotherapy.
This Research Topic aims to provide a systematic understanding of the interactions between RBPs and their non-coding RNA targets (ncRNAs) to expand our knowledge of tumor biology and ultimately discover potential new anti-cancer therapeutic targets.
We welcome high-quality Original Research Articles and Review Articles that give new evidence and summarize current data to better understand how RBPs and RNA molecules (especially ncRNAs) act together in cancer and how their interplays make tumors resistant to various treatments.
Topics covered in these Research Topic may include, but are not limited to, the following:
- Identifying genetic and epigenetic factors that affect RBP expression
- Roles of RBPs and their partner ncRNAs in epithelial-to-mesenchymal transition (EMT), cancer stem cells (CSCs), cancer angiogenesis, cancer immunity, and cancer metabolism
- RBPs and their partner ncRNAs as vital cancer diagnostic and prognostic biomarkers
- Clarification of the molecular association between RBPs and mRNAs or ncRNAs in tumors
- RBPs and their associated ncRNAs as potential therapeutic options for suppressing metastasis and overcoming treatment resistance
- Innovative methods for identifying and characterizing RBPs and their ncRNA targets in tumors
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Resistance to chemotherapy, targeted therapy, and immune therapy are the leading causes of cancer treatment failure and death. RNA-binding proteins (RBPs) interact with RNA elements in a dynamic manner, modulating mRNA processing, stability, transport, and translation. RBPs have recently been discovered to regulate the stability and localization of long non-coding RNAs (lncRNAs). RBPs may also bind circular RNAs (circRNAs) and play important roles in circRNA production and degradation. RBPs are often dysregulated in human cancers, and they control the expression and activity of oncogenic and tumor-suppressor proteins, which govern tumor response to different therapies such as chemotherapy, targeted therapy, and immunotherapy.
This Research Topic aims to provide a systematic understanding of the interactions between RBPs and their non-coding RNA targets (ncRNAs) to expand our knowledge of tumor biology and ultimately discover potential new anti-cancer therapeutic targets.
We welcome high-quality Original Research Articles and Review Articles that give new evidence and summarize current data to better understand how RBPs and RNA molecules (especially ncRNAs) act together in cancer and how their interplays make tumors resistant to various treatments.
Topics covered in these Research Topic may include, but are not limited to, the following:
- Identifying genetic and epigenetic factors that affect RBP expression
- Roles of RBPs and their partner ncRNAs in epithelial-to-mesenchymal transition (EMT), cancer stem cells (CSCs), cancer angiogenesis, cancer immunity, and cancer metabolism
- RBPs and their partner ncRNAs as vital cancer diagnostic and prognostic biomarkers
- Clarification of the molecular association between RBPs and mRNAs or ncRNAs in tumors
- RBPs and their associated ncRNAs as potential therapeutic options for suppressing metastasis and overcoming treatment resistance
- Innovative methods for identifying and characterizing RBPs and their ncRNA targets in tumors
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
