About this Research Topic
Nucleosides, nucleotides and nucleic acids play a central role in the treatment of different diseases with emphasis on viral infections and cancer. The recent outbreaks of new life-threatening viruses resulted in a boost in new achievements on this area with new nucleosides and their derivatives being approved for treatment of these viral infections. Additionally, the understanding of the nucleoside, nucleotide and nucleic acid chemistry and biochemistry allowed the development of the RNA vaccines, an important breakthrough in the recent treatment of SARS-CoV-2 and also with great potential in the treatment of other diseases. This Research Topic aims to discuss these developments and their impact in the future of the field that may lead to new achievements.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Synthetic methodologies to access non-natural nucleosides, nucleotides, prodrugs as well as RNA/DNA synthesis
• Conformational studies
• RNA therapeutics including vaccines and antisense oligonucleotides
• Structural investigations
• Imaging
• Biosensors
Keywords: Nucleos(t)ides, Synthetic methodologies, Imaging
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.