About this Research Topic
Diet is one of the most important modifiable factors for human health. Higher intakes of foods including vegetables, fruits, whole grains, and beans have been associated with lower risks of numerous chronic conditions especially cardiometabolic disorders. Meanwhile, higher intakes of nutrients such as unsaturated fatty acids, vitamins, and antioxidants and lower intakes of saturated fatty acids, salt, and sugar may have potential benefits for health. Recent research has highlighted the importance of dietary patterns including the Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets on the development of cardiovascular diseases. Circulating metabolites such as branched-chain amino acids have been associated with cardiometabolic disorders. However, the impact of these dietary factors in neurodegenerative disorders especially dementia/cognitive impairment/brain damage remains largely unclear.
Genetics such as apolipoprotein E Ɛ4 play an important role in the development of dementia/cognitive impairment/brain damage. Recent evidence has suggested a significant interaction between genetic risk score and lifestyle for risk of dementia and cognitive impairment. However, it is largely unknown regarding the interaction between genetics and diet for these neurodegenerative disorders. It is also of great interest to examine whether dietary factors mediate the association between genetics and neurodegenerative disorders. The findings would provide evidence on specific dietary guidelines for individuals with a high risk of susceptibility to neurodegenerative disorders.
This Research Topic aims to provide new knowledge on how to promote cognitive health by modification of dietary habits. In addition, we wish to identify the interaction between genetics and diet for neurodegenerative disorders.
Subtopics of interests include, but are not limited to:
1. Examining the association between intakes of individual nutrients and foods and neurodegenerative disorders/mental disorders and healthy aging in older adults.
2. Examining the association between diet score and neurodegenerative disorders/mental disorders, and healthy aging in older adults.
3. Examining the association between diet and genetics (genetic risk score) for the development of neurodegenerative disorders/mental disorders and healthy aging in older adults.
Keywords: diet, nutrient, food, diet quality, genetics, dementia, cognition, healthy aging, interaction
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