About this Research Topic
However, the gut microbiota is extremely susceptible to diet, drugs, and various environmental pollutants. Many environmental pollutants can induce the imbalance of intestinal flora, and then have many adverse effects on creatural health. Among many environmental pollutants, heavy metals such as molybdenum and cadmium have received extensive attention due to their unique toxicological effects. They induce pathological injuries such as carcinogenesis, oxidative stress, and DNA damage, and affect the immune system. Molybdenum and cadmium absorbed by the intestine are transported to the target organs through the bloodstream, with severe detrimental effects on animal health. However, high concentrations of non-absorbed heavy metals are present in the intestinal microenvironment and they may cause devastating damage to the ecological balance of intestinal microorganisms and their physiological functions.
The purpose of this Research Topic is to highlight and stimulate discussion on the intestinal microflora of the ruminant and its relationship to the toxicology of heavy metals such as molybdenum and cadmium. We welcome mini-reviews, full-length reviews, and original research papers dealing with the following subtopics:
• Effects of intestinal microbe composition on heavy metals to body damage
• Toxicology of heavy metals and studies of intestinal microbiome and metabolites associated with animal metabolic health
• The effects of an environmentally relevant level of heavy metals on the gut microbiome and its functional metagenome
• Effects of heavy metal exposure on intestinal microflora and intestinal-related immune status
• The effects of heavy metal exposure on intestinal microbiome development, key metabolites, and metabolic pathways studied by multi-omics
Keywords: Heavy Metals, Toxicology, Intestinal Microbiome, Metabonomics, Transcriptome
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