Understanding how systemic immunity affects disease development and treatment is one of the most challenging questions in immunology. This question is involved in many immunologic and inflammatory diseases such as infectious, cardiovascular, cancer, metabolic disorders, and neurodegeneration. Take cancer for example, many compositional and functional alterations in the immune system were systemically induced. Recent preclinical and clinical studies unraveled the key role of systemic immune perturbations in cancer development and the effect of circulating immune cells on the antitumor immune response. Modulating immune responses and immunotherapeutic approaches have successfully shown their therapeutic effect in many cancer types. It is important to study the relationship between systematic immune functions and diseases and to explore and identify novel drugs modulating systematic immunity for understanding and treating immunologic and inflammatory diseases.
In this Research Topic, we would like to explore the novel aspects of the drug discovery and translational application involving the regulation of immune system function, especially from a global immune landscape perspective, in immune-related diseases.
We welcome the submission of Original Research Articles, Reviews, Mini-Reviews, and Perspectives covering, but not limited to, the following topics:
• Preclinical or clinical evaluation of drugs in the prevention and treatment of immune-related diseases, including type 1 diabetes, cancer, neurodegeneration, respiratory infection, COVID-19, etc.
• Exploration and development of novel drugs as immunomodulators.
• Integrating multi-omics approaches, such as proteomics, immunomics, microbic genomics, and metabolomics, in preventing and treating immune-related diseases.
• Strategies and methodologies in screening and identification of immunotherapy sensitization drugs.
• Drug resistance and safety, and drug-drug interactions in immunotherapy.
• Immune regulation and pharmacology in inflammation.
• Immune profiling and T-cell or B-cell receptor repertoires sequencing in health and disease; the development, programming, and regulatory mechanisms of the immune system.
Please note that Original research based solely on in silico techniques will not be considered for review.
This Research Topic does not accept publication studies carried out with crude extracts or mixtures. Only the use of highly purified, chemically characterized compounds is acceptable.
Whenever a complex mixture is used, data with the single components of the mixture, in precisely defined dose/concentration, should be provided (and/or previously published). This also applies to in silico studies on supposed mechanisms underlying supposed actions of crude extracts and/or mixtures.
Understanding how systemic immunity affects disease development and treatment is one of the most challenging questions in immunology. This question is involved in many immunologic and inflammatory diseases such as infectious, cardiovascular, cancer, metabolic disorders, and neurodegeneration. Take cancer for example, many compositional and functional alterations in the immune system were systemically induced. Recent preclinical and clinical studies unraveled the key role of systemic immune perturbations in cancer development and the effect of circulating immune cells on the antitumor immune response. Modulating immune responses and immunotherapeutic approaches have successfully shown their therapeutic effect in many cancer types. It is important to study the relationship between systematic immune functions and diseases and to explore and identify novel drugs modulating systematic immunity for understanding and treating immunologic and inflammatory diseases.
In this Research Topic, we would like to explore the novel aspects of the drug discovery and translational application involving the regulation of immune system function, especially from a global immune landscape perspective, in immune-related diseases.
We welcome the submission of Original Research Articles, Reviews, Mini-Reviews, and Perspectives covering, but not limited to, the following topics:
• Preclinical or clinical evaluation of drugs in the prevention and treatment of immune-related diseases, including type 1 diabetes, cancer, neurodegeneration, respiratory infection, COVID-19, etc.
• Exploration and development of novel drugs as immunomodulators.
• Integrating multi-omics approaches, such as proteomics, immunomics, microbic genomics, and metabolomics, in preventing and treating immune-related diseases.
• Strategies and methodologies in screening and identification of immunotherapy sensitization drugs.
• Drug resistance and safety, and drug-drug interactions in immunotherapy.
• Immune regulation and pharmacology in inflammation.
• Immune profiling and T-cell or B-cell receptor repertoires sequencing in health and disease; the development, programming, and regulatory mechanisms of the immune system.
Please note that Original research based solely on in silico techniques will not be considered for review.
This Research Topic does not accept publication studies carried out with crude extracts or mixtures. Only the use of highly purified, chemically characterized compounds is acceptable.
Whenever a complex mixture is used, data with the single components of the mixture, in precisely defined dose/concentration, should be provided (and/or previously published). This also applies to in silico studies on supposed mechanisms underlying supposed actions of crude extracts and/or mixtures.
