About this Research Topic
Nucleic-acid-based therapeutic and diagnostic approaches gain increasing recognition each year. Among those, G-quadruplexes have recently become one of the most outstanding classes of nucleic acid structures which can serve as prospective targets naturally occurring in cells and acting like triggers in such pivotal cellular processes like replication, transcription or translation. On the other hand, G-quadruplexes have been already proven to be potent molecular tools in various diseases treatments as well as in diagnostic approaches. Noteworthy, their outstanding properties e.g. ease of storage and balanced costs of synthesis, high enzymatic resistance, increased cellular uptake, and broad range of chemical modifications made G-quadruplexes interesting rival to antibodies. The main aim of this Research Topic is to gather up to date findings in the research area of therapeutic and diagnostic approaches targeted towards G-quadruplex structures in vivo or artificial G-quadruplexes.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Synthetic G-quadruplexes with therapeutic or diagnostic potential
• G-quadruplex based aptamers
• Strategies of cellular processes regulation based on G-quadruplex targeting
Keywords: G-quadruplexes, Aptamers, G-rich oligonucleotides, Therapeutics, Diagnostic tools, Gene regulation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.