About this Research Topic
Obesity is an increasing global public health issue. It has been linked with several health problems, such as hypertension, diabetes, non-alcoholic fatty liver disease, chronic kidney disease, mental health disorders, and some types of cancer. In addition to reducing the life expectancy and increasing morbidity, obesity has a negative social and economic impact. Several studies have also described its negative impact on health-related quality of life, especially in women.
Pathophysiologically, obesity is a proinflammatory condition, involving abnormalities in neuroendocrine pathways, and altered control of food intake usually related to an excessive energy intake that generates an excessive accumulation of triacylglycerols in adipose tissue. However, it has been shown that obesity also has an important genetic component associated with excessive weight gain. In general terms, this interaction of environmental and genetic factors results in a pro-inflammatory state, characterized by a higher level of body lipids, oxidative stress, and expression of inflammatory markers.
To date, bariatric surgery is considered an effective treatment for comorbidities and metabolic complications associated with morbid obesity. However, in many countries, access to this treatment is limited and patients usually have to pay for it out-of-pocket.
This Research Topic aims to cover cutting-edge basic, epidemiological, and clinical research, as well as state-of-the-art reviews covering different aspects of obesity, metabolic disorders, and bariatric surgery, with sub-topics including:
- Epidemiology of overweight/obesity and metabolic-related disorders
- Metabolic pathways and pathophysiology of obesity-related diseases
- Obesity treatment and evidence-based decision making.
- Economic impact of obesity
- Obesity and all-cause mortality
- Gender differences in obesity-related comorbidities
- Novel methods for the diagnosis of metabolic disorders
- Obesity prevention policies
- Weight bias and obesity stigma
- Maternal obesity and bariatric surgery
- Bariatric surgery and maternal health
- Cost-effectiveness of bariatric surgery
- Short-, medium- and long-term metabolic outcomes of bariatric surgery
- Psychosocial outcomes of bariatric surgery
Pathophysiologically, obesity is a proinflammatory condition, involving abnormalities in neuroendocrine pathways, and altered control of food intake usually related to an excessive energy intake that generates an excessive accumulation of triacylglycerols in adipose tissue. However, it has been shown that obesity also has an important genetic component associated with excessive weight gain. In general terms, this interaction of environmental and genetic factors results in a pro-inflammatory state, characterized by a higher level of body lipids, oxidative stress, and expression of inflammatory markers.
To date, bariatric surgery is considered an effective treatment for comorbidities and metabolic complications associated with morbid obesity. However, in many countries, access to this treatment is limited and patients usually have to pay for it out-of-pocket.
This Research Topic aims to cover cutting-edge basic, epidemiological, and clinical research, as well as state-of-the-art reviews covering different aspects of obesity, metabolic disorders, and bariatric surgery, with sub-topics including:
- Epidemiology of overweight/obesity and metabolic-related disorders
- Metabolic pathways and pathophysiology of obesity-related diseases
- Obesity treatment and evidence-based decision making.
- Economic impact of obesity
- Obesity and all-cause mortality
- Gender differences in obesity-related comorbidities
- Novel methods for the diagnosis of metabolic disorders
- Obesity prevention policies
- Weight bias and obesity stigma
- Maternal obesity and bariatric surgery
- Bariatric surgery and maternal health
- Cost-effectiveness of bariatric surgery
- Short-, medium- and long-term metabolic outcomes of bariatric surgery
- Psychosocial outcomes of bariatric surgery
Keywords: obesity, overweight, metabolic disorders, bariatric surgery
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