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Manuscript Submission Deadline 08 February 2023

Early-life environmental factors, in particular nutritional factors, played key elements in the etiology of cardiometabolic diseases in later life, and changes in maternal nutrition are correlated with adverse health outcomes both mother in later life but also in offspring across the life course. Hence, ...

Early-life environmental factors, in particular nutritional factors, played key elements in the etiology of cardiometabolic diseases in later life, and changes in maternal nutrition are correlated with adverse health outcomes both mother in later life but also in offspring across the life course. Hence, clarifying the contribution and effect of nutrients in the progression of chronic complex diseases in multifactorial conditions is the most challengeable to promoting public health nutrition advances. For example, periconceptional insufficiency (including maternal and paternal intake) of one-carbon metabolism nutrients (folate, vitamin B12, etc.) increased the risk of neural tube defects as well as other adverse health outcomes. Epigenetic mechanism related to the development of multifactorial disease states from infant to adulthood, including but not limited to diabetes mellitus, and insulin resistance would be investigated. Besides the early epidemiological observations, cells and animal models used to examine the impact of early life programming are needed. Emerging potential mechanisms, interventions, and frameworks to explore across generation effects also needed to be developed.

This Research Topic aims to contribute to filling the gap in the knowledge about health effects of life events, nutrition status, dietary and supplementation across the life course on health by presenting epidemiology, mechanism, and intervention study. Possible new mechanisms which used current and novel methodologies detected and discovered as well as new theories about this field could be summarized.

· Epidemiology evidence to explore effects of dietary supplements including folic acid and other one-carbon nutrients on the health of both women and men;

· Prospective epidemiology study which explored effects of malnutrition, and childhood adversity on health across generations;

· Pathophysiological mechanisms on how nutrients and metabolites could have an impact on health;

· Preclinical models used to explore altered maternal and paternal nutrition on the health of the next generation;

· Investigate possible mechanisms and specific nature of health benefits and risks of one-carbon nutrients.

Keywords: prenatal nutrition, dietary supplementation, one-carbon metabolism nutrients, life cycle, pathophysiological mechanisms


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