About this Research Topic
We will review early animal and human studies and those which led to the development of changes in transplant protocols such as peripheral blood stem cell and cord blood transplants and the harnessing of graft versus leukaemia (GvL) effects by donor lymphocyte infusions. The Research Topic will cover immunogenetics, the role of biomarkers, and future developments of the therapy which will aim to further improve the outcome for haematopoietic stem cell transplant patients.
The Research Topic will be divided into 8 chapters dealing with animal studies; a history of early human studies; the pathophysiology of HSCT; graft versus host disease; graft versus leukaemia effects; immune reconstitution; immunogenetics; and future developments including use of mesenchymal stem cells, virus specific T cells and chimeric antigen receptor (CAR) therapy.
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