About this Research Topic
This Research Topic aims to highlight immunotherapeutic strategies that were originally developed to treat cancer and have since been adapted and/or repurposed to treat autoimmune disorders, transplant rejection, allergies or other inflammatory disorders. We aim to discuss the progress made in adapting these approaches, the lessons learned from cancer immunotherapy, the caveats and pitfalls currently faced, and how the latter can be overcome to bring tolerance-inducing immunotherapies to the clinic.
This Research Topic invites the submission of Original Research and Review/mini-Review articles focusing on immunotherapeutic strategies that can be modified to treat autoimmune diseases, transplant rejection, and/or inflammatory disorders.
Examples of such treatment options are outlined below, although this is not an exhaustive list and articles related to similar therapeutic approaches are more than welcome.
– Cytokine immunotherapies and related strategies, including cytokine muteins, cytokine complexes, and orthogonal cytokine/receptor pairings
– Monoclonal antibody immunotherapies and related engineered derivatives, such as bispecific antibodies, antibody fragments, and antibody/drug conjugates
– Adoptive cell therapies, related cell isolation techniques, and/or genetic engineering techniques to enhance and/or manipulate the function of these cells e.g. using chimeric antigen receptors to confer specificity to regulatory T cells
Keywords: cancer therapy, autoimmunity, tolerance, transplantation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.