Persistent infection occurs when the primary infection is not cleared by the immune response, which lasts for long periods and is accompanied by the complex interaction between the host immune system and the virus. Persistent infection with pathogens, such as human immunodeficiency virus (HIV), hepatitis B (HBV), and C virus (HCV), SARS-COV-2, foot-and-mouth disease virus(FMDV) and a number of herpes viruses are the etiological factors for the development of related diseases, which need to be deeply studied for the exploration of potential infection mechanisms and therapeutic approaches. Emerging studies demonstrated the host cellular metabolic changes provided potential targets and strategies for infectious disease treatment or diagnosis. However, the metabolic changes in host cells during persistent viral infection, including effects on energy metabolism, glutaminolysis and fatty acid metabolism remains to be further understood. Manipulating those procedures may influence the outcome of persistent infection and could lead to the development of potential novel therapeutic avenues.
The focus of the research topic is to highlight current research that aims to understand metabolic changes in target cells in persistent infection or chronic infection scenarios, and to explore the impact of downstream interferon activation on cellular metabolic events. It is equally important to investigate the relationship between metabolic diseases and the outcome of persistent viral Infection. Reverse those metabolic events aiming at reshaping the consequence of the viral infection, therefore proposing novel therapeutic avenues for viral infection and refining the design strategy of vaccines.
We welcome Original Research Articles, Brief Research Reports, and Review Articles that focus on the interaction between cellular and host mechanisms involved in cell metabolism to virus persistent infection and associated viral immune evasion strategies. Submissions that explore, but are not limited to, the following topics are especially welcome:
1. Cellular metabolism of infected cells in virus persistent infection.
2. Metabolism of innate Immune and adaptive immune response effector cells during the virus persistent infection.
3. The molecular mechanisms of viral persistent infection and viral pathogenesis of related diseases, and the role of host immune during these processes.
4. Antiviral approaches to eliminating or silencing the activity of viruses during the persistent infection.
Persistent infection occurs when the primary infection is not cleared by the immune response, which lasts for long periods and is accompanied by the complex interaction between the host immune system and the virus. Persistent infection with pathogens, such as human immunodeficiency virus (HIV), hepatitis B (HBV), and C virus (HCV), SARS-COV-2, foot-and-mouth disease virus(FMDV) and a number of herpes viruses are the etiological factors for the development of related diseases, which need to be deeply studied for the exploration of potential infection mechanisms and therapeutic approaches. Emerging studies demonstrated the host cellular metabolic changes provided potential targets and strategies for infectious disease treatment or diagnosis. However, the metabolic changes in host cells during persistent viral infection, including effects on energy metabolism, glutaminolysis and fatty acid metabolism remains to be further understood. Manipulating those procedures may influence the outcome of persistent infection and could lead to the development of potential novel therapeutic avenues.
The focus of the research topic is to highlight current research that aims to understand metabolic changes in target cells in persistent infection or chronic infection scenarios, and to explore the impact of downstream interferon activation on cellular metabolic events. It is equally important to investigate the relationship between metabolic diseases and the outcome of persistent viral Infection. Reverse those metabolic events aiming at reshaping the consequence of the viral infection, therefore proposing novel therapeutic avenues for viral infection and refining the design strategy of vaccines.
We welcome Original Research Articles, Brief Research Reports, and Review Articles that focus on the interaction between cellular and host mechanisms involved in cell metabolism to virus persistent infection and associated viral immune evasion strategies. Submissions that explore, but are not limited to, the following topics are especially welcome:
1. Cellular metabolism of infected cells in virus persistent infection.
2. Metabolism of innate Immune and adaptive immune response effector cells during the virus persistent infection.
3. The molecular mechanisms of viral persistent infection and viral pathogenesis of related diseases, and the role of host immune during these processes.
4. Antiviral approaches to eliminating or silencing the activity of viruses during the persistent infection.
