Vast quantities of antibiotics and pesticides have been widely applied in various fields to kill the plant and human pathogens, resulting in increased pathogen resistance and decreased effectiveness of such chemicals. Thus, there is a need for more safe and more eco-friendly strategies as compared to chemical prevention. Quorum sensing (QS) is an intercellular communication mechanism in a bacterial population, through which bacteria adjust their population density and behavior upon sensing the levels of signaling molecules in the environment. As an alternative, quorum quenching, which disrupts QS either by degradation of QS signals or interference of signal generation or perception, is a promising strategy for the prevention and control of QS-mediated bacterial infections. In recent years, quorum quenching based on QS has been adopted as a potential biocontrol approach for controlling various diseases due to its relationship with pathogenic multi-antibiotic-resistant microorganisms.
This Research Topic aims to gather Original Research and Review articles that focus on the role of bacterial quorum sensing and quorum quenching in pathogenic microorganisms. In particular, studies targeting quorum quenching for the treatment or prevention of QS-related infections are very welcome.
Topics of interest include, but are not limited to:
• Role of quorum sensing in microbial pathogenicity
• Role of quorum sensing in beneficial microbial interactions
• Mechanisms of quorum sensing circuits and target control
• Quorum quenching via the degradation of quorum sensing signals or interference of signal generation or perception
• Biocontrol based on quorum quenching
• Biofilm formation in degrading microorganisms
Vast quantities of antibiotics and pesticides have been widely applied in various fields to kill the plant and human pathogens, resulting in increased pathogen resistance and decreased effectiveness of such chemicals. Thus, there is a need for more safe and more eco-friendly strategies as compared to chemical prevention. Quorum sensing (QS) is an intercellular communication mechanism in a bacterial population, through which bacteria adjust their population density and behavior upon sensing the levels of signaling molecules in the environment. As an alternative, quorum quenching, which disrupts QS either by degradation of QS signals or interference of signal generation or perception, is a promising strategy for the prevention and control of QS-mediated bacterial infections. In recent years, quorum quenching based on QS has been adopted as a potential biocontrol approach for controlling various diseases due to its relationship with pathogenic multi-antibiotic-resistant microorganisms.
This Research Topic aims to gather Original Research and Review articles that focus on the role of bacterial quorum sensing and quorum quenching in pathogenic microorganisms. In particular, studies targeting quorum quenching for the treatment or prevention of QS-related infections are very welcome.
Topics of interest include, but are not limited to:
• Role of quorum sensing in microbial pathogenicity
• Role of quorum sensing in beneficial microbial interactions
• Mechanisms of quorum sensing circuits and target control
• Quorum quenching via the degradation of quorum sensing signals or interference of signal generation or perception
• Biocontrol based on quorum quenching
• Biofilm formation in degrading microorganisms
