Research Topic

Muscle fatigue and muscle weakness: what we know and what we wish we did

About this Research Topic

The purpose of this Research Topic is to discuss evidence coming from macroscopic observations on the whole human/animal to investigations at the molecular level in an effort to identify critical factors in muscle fatigue and muscle weakness, in health and disease.
...

The purpose of this Research Topic is to discuss evidence coming from macroscopic observations on the whole human/animal to investigations at the molecular level in an effort to identify critical factors in muscle fatigue and muscle weakness, in health and disease.

Why is this important?

Skeletal muscles confer movement to the human body using vast amounts of energy provided through complex metabolic pathways. Thus, whole body mobility and energy balance are dictated by muscle contraction. On the other side, muscle function reflects overall health status, as chronic conditions and/or ageing affect either or both of muscle quality (protein and fat content) and quantity (mass). In health, muscle fatigue is temporary and recovery occurs rapidly. In ageing or chronic disease however, muscle fatigue may occur prematurely and be persistent, endangering thus a person’s safety (i.e. weakness leads to falls), and leading the sufferer in a self-perpetuating vicious cycle of inactivity -> disuse muscle atrophy/metabolic disturbance and so on, that compounds morbidity (i.e. causing metabolic syndrome, fatness, hypertension, muscle cachexia) and that eventually leads to premature death.

Research in skeletal muscle physiology and biophysics is at an exciting phase. The advent of new methodologies and technological advancements have allowed researchers to advance our knowledge on the “how’s” and “why’s” of muscle contraction – however there are still many unanswered questions especially when disease states are implicated.

Such questions need addressing if as a scientific community we aspire to secure better designed interventions to improve muscle function, and thus improve quality of life and life prognosis for the ageing population and chronic disease patients.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top