Severe infectious diseases are major life-threatening issues, especially for immunosuppressed hosts whose adaptive immune response is suppressed. Pathogens of severe infectious diseases usually cannot be eliminated by antibiotics or other drugs alone, leading to increased mortality. Sepsis, a potentially life-threatening condition caused by response to the infection, occurs when immune response is out of balance, triggering changes that can damage multiple organ systems. However, whether changes in immune function during the development of sepsis are associated with the prognosis is still uncertain. The optimal timing and the most appropriate patients for the use of thymic fassin or gamma globulin are still under debate. Therefore, it is essential to further analyze immune function and the regulation in severe infection and make appropriate adjustments based on monitoring of immune function, to ultimately improve the clinical prognosis of immunosuppressed patients with severe infection.
This Research Topic aims at gaining deep insight into immune function monitoring and regulation in severe infectious diseases. We hope to increase our interest in the changes in immune function during severe infection and enhance clinical understanding, therefore making appropriate adjustments based on close monitoring of immune function and ultimately improve the clinical prognosis of immunosuppressed patients with severe infection.
Submissions of studies focusing on, but not limited to, the following points are highly welcome:
1. Monitoring immunomodulation in patients with sepsis and severe infectious diseases.
2. Immune functional assays, from custom to standardized tests for precision medicine in sepsis and severe infectious diseases.
3. Assessment of immune organ dysfunction in sepsis and severe infectious diseases
4. Advances in immune monitoring approaches for sepsis-induced immunosuppression.
5. Novel biomarkers and techniques for diagnosis, prognosis, and prediction of sepsis and severe infectious diseases based on dynamic monitoring of immune function.
6. Update on innate and adaptive immunity in severe infection.
7. Immune response at the cellular and molecular level in patient with infectious diseases such as COVID-19.
Severe infectious diseases are major life-threatening issues, especially for immunosuppressed hosts whose adaptive immune response is suppressed. Pathogens of severe infectious diseases usually cannot be eliminated by antibiotics or other drugs alone, leading to increased mortality. Sepsis, a potentially life-threatening condition caused by response to the infection, occurs when immune response is out of balance, triggering changes that can damage multiple organ systems. However, whether changes in immune function during the development of sepsis are associated with the prognosis is still uncertain. The optimal timing and the most appropriate patients for the use of thymic fassin or gamma globulin are still under debate. Therefore, it is essential to further analyze immune function and the regulation in severe infection and make appropriate adjustments based on monitoring of immune function, to ultimately improve the clinical prognosis of immunosuppressed patients with severe infection.
This Research Topic aims at gaining deep insight into immune function monitoring and regulation in severe infectious diseases. We hope to increase our interest in the changes in immune function during severe infection and enhance clinical understanding, therefore making appropriate adjustments based on close monitoring of immune function and ultimately improve the clinical prognosis of immunosuppressed patients with severe infection.
Submissions of studies focusing on, but not limited to, the following points are highly welcome:
1. Monitoring immunomodulation in patients with sepsis and severe infectious diseases.
2. Immune functional assays, from custom to standardized tests for precision medicine in sepsis and severe infectious diseases.
3. Assessment of immune organ dysfunction in sepsis and severe infectious diseases
4. Advances in immune monitoring approaches for sepsis-induced immunosuppression.
5. Novel biomarkers and techniques for diagnosis, prognosis, and prediction of sepsis and severe infectious diseases based on dynamic monitoring of immune function.
6. Update on innate and adaptive immunity in severe infection.
7. Immune response at the cellular and molecular level in patient with infectious diseases such as COVID-19.
