About this Research Topic
Metabolomics can critically assess key metabolic pathways and thus provide data for nutritional deficiencies, metabolic imbalance, environmental burden, and the gut microbiome. Since the metabolite functions are not determined by epigenetic regulation or post-translational modification, quantification and evaluation of metabolites is an highly effective method to capture time-dependent fluctuations and cellular metabolic state, even prior to disease onset.
Blood serum is a primary carrier of small molecules in the body, present in the blood of every tissue and organ in the body. It plays a critical role in transporting dissolved gases, nutrients, hormones and metabolic wastes, as well as in the regulation of the pH and ion composition of interstitial fluids, the restriction of fluid losses at injury sites and the defence against toxins and pathogens.
Most of today’s clinical tests are based on the analysis of blood plasma and blood serum because their chemical and protein composition can be altered by tissue lesions, organ dysfunctions and pathological states. Serum does not only reflect changes at genomic and proteomic levels but is also influenced by environmental factors, making it an ideal sample for disease diagnosis, monitoring and mechanistic investigations.
In this context, the goal of this Research Topic is to expand scientific knowledge and insights on the use of the serum metabolome in disease diagnostics and disease therapeutic approaches.
We welcome manuscripts that cover, but are not limited to, the following areas:
• Serum metabolite biomarkers for disease treatment responses/effect
• Serum metabolomic patterns in disease
• Dietary patterns and the serum metabolome in health and disease
• Serum metabolomics and gut microbiota activity
• Application of serum metabolomics for environmental risk assessment
• Application of serum metabolomics for pharmacological assessment
• Application of serum metabolomics for differentiating and predicting pathological types
• Application of serum metabolomics for mechanistic understanding of pathology and progression of diseases
• Application of serum metabolomics for mechanistic understanding of molecule mechanisms under treatments or intervenes (drugs, nutrients and exercises, etc).
Blood serum is a primary carrier of small molecules in the body, present in the blood of every tissue and organ in the body. It plays a critical role in transporting dissolved gases, nutrients, hormones and metabolic wastes, as well as in the regulation of the pH and ion composition of interstitial fluids, the restriction of fluid losses at injury sites and the defence against toxins and pathogens.
Most of today’s clinical tests are based on the analysis of blood plasma and blood serum because their chemical and protein composition can be altered by tissue lesions, organ dysfunctions and pathological states. Serum does not only reflect changes at genomic and proteomic levels but is also influenced by environmental factors, making it an ideal sample for disease diagnosis, monitoring and mechanistic investigations.
In this context, the goal of this Research Topic is to expand scientific knowledge and insights on the use of the serum metabolome in disease diagnostics and disease therapeutic approaches.
We welcome manuscripts that cover, but are not limited to, the following areas:
• Serum metabolite biomarkers for disease treatment responses/effect
• Serum metabolomic patterns in disease
• Dietary patterns and the serum metabolome in health and disease
• Serum metabolomics and gut microbiota activity
• Application of serum metabolomics for environmental risk assessment
• Application of serum metabolomics for pharmacological assessment
• Application of serum metabolomics for differentiating and predicting pathological types
• Application of serum metabolomics for mechanistic understanding of pathology and progression of diseases
• Application of serum metabolomics for mechanistic understanding of molecule mechanisms under treatments or intervenes (drugs, nutrients and exercises, etc).
Keywords: serum, metabolites, pathogen, disease treatment, serum metabolome, molecule mechanism
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
