Microbiota composition imbalances are associated with the development of allergic diseases. The microbiota regulates the immune response. These range from cell development to organ and tissue formation, exerting their influence through multiple interactions with the innate and acquired branches of the immune system. In balancing the activity of Th1, Th2, and Th17 cells, the microbiome is important in developing effector or tolerogenic responses to different antigens. For example, mucosal CD103+ dendritic cells (DCs), which are influenced by gut microbiota, promote the differentiation of regulatory T cells (Tregs) and attenuate OVA-induced allergic inflammation.
Therefore, the microbiome can be considered a therapeutic target for the treatment of allergic diseases. However, the possible mechanisms of microbial action, distinguishing between protective microorganisms and those associated with an increased risk of allergic diseases, and the role of microbiomes in the development and function of the immune system remain largely unknown.
The aim of this Research Topic is to provide deeper insights into the mechanisms of the interaction between microorganisms and allergic/immune diseases as well as explore microbiota influences and mechanisms linking innate and adaptive immunity in allergic diseases. In addition, it will explore the mechanisms of interaction between the microbiome and host immunity in allergic diseases, including changes induced by microbial-associated infections, cytokines, and immune responses.
This Research Topic welcomes Original Research, Review, and Mini Review. Sub-topics include, but are not limited to:
1. Food allergy/Asthma/Atopic Dermatitis/Allergic Rhinitis/Eczema microbiota
2. Progress and current understanding of different aspects of basic and applied research related to the mechanisms of allergic diseases and microbial interactions
3. New mechanism of microbial-host immune interaction in allergic diseases
Microbiota composition imbalances are associated with the development of allergic diseases. The microbiota regulates the immune response. These range from cell development to organ and tissue formation, exerting their influence through multiple interactions with the innate and acquired branches of the immune system. In balancing the activity of Th1, Th2, and Th17 cells, the microbiome is important in developing effector or tolerogenic responses to different antigens. For example, mucosal CD103+ dendritic cells (DCs), which are influenced by gut microbiota, promote the differentiation of regulatory T cells (Tregs) and attenuate OVA-induced allergic inflammation.
Therefore, the microbiome can be considered a therapeutic target for the treatment of allergic diseases. However, the possible mechanisms of microbial action, distinguishing between protective microorganisms and those associated with an increased risk of allergic diseases, and the role of microbiomes in the development and function of the immune system remain largely unknown.
The aim of this Research Topic is to provide deeper insights into the mechanisms of the interaction between microorganisms and allergic/immune diseases as well as explore microbiota influences and mechanisms linking innate and adaptive immunity in allergic diseases. In addition, it will explore the mechanisms of interaction between the microbiome and host immunity in allergic diseases, including changes induced by microbial-associated infections, cytokines, and immune responses.
This Research Topic welcomes Original Research, Review, and Mini Review. Sub-topics include, but are not limited to:
1. Food allergy/Asthma/Atopic Dermatitis/Allergic Rhinitis/Eczema microbiota
2. Progress and current understanding of different aspects of basic and applied research related to the mechanisms of allergic diseases and microbial interactions
3. New mechanism of microbial-host immune interaction in allergic diseases
