About this Research Topic
The elderly population develop inflamageing, accompanied with elevated levels of blood inflammatory markers that has a high susceptibility to chronic morbidity, disability, frailty, and even mortality. Inflamageing, an age-related increase of pro-inflammatory markers in blood and tissues, is a risk factor in both cardiovascular diseases (CVDs) and brain diseases. Such subtle but chronic low-grade inflammation could be caused by external and internal stressors. Despite of canonical immune cells, recent studies have shown that inflamageing also involves non-immune cells, including adipocytes, fibroblasts, muscle, endothelial, and senescent cells. This dynamic phenomenon, and its final outcome is highly diversified depending on both genetics and epigenetics of individuals. Hence, it is imperative to unveil the underlying molecular mechanisms of inflamageing and to explore the potential therapeutic strategies.
In this research topic, we expect to understand the progression of inflammageing related diseases, including cancer, CVDs, Alzheimer’s diseases, neurovascular diseases, and endocrine diseases from an immunological perspective. Also, exploration of the key factors and novel pathways involved in this dynamic phenomenon is encouraged. Studies of different levels from cells to animal models are welcomed to address the conceptual framework of disease progression. By discussing about modulating inflammageing, we aim to find promising strategies not only to prevent age-related diseases but also to slow the decline of health that occurs with ageing. With the emerging field of cell therapy and biological drug, discovery of new treatment and prevention of inflammageing and age-related diseases can be achieved.
All scientists and researchers interested in this Research Topic are invited to submit their work in the form of Original Research, Review, and Mini-Review articles, offering new insights within the inflamageing perspective. We welcome manuscripts focusing on, but not limited to, the following sub-topics:
• Articles covering the clinical and research fields in age-related diseases, with a focus on emerging issues and treatments in inflammageing from an immunological perspective.
• Molecular and cellular insights into the mechanisms underlying the progress of inflammation in aging.
• Immunological aspects of degenerative diseases from an inflammaging perspective including, but not limited to: Cancer, CVDs, Alzheimer’s diseases, Neurovascular diseases, and Endocrine diseases.
• Novel treatments and drug discovery of modulating inflammageing.
In this research topic, we expect to understand the progression of inflammageing related diseases, including cancer, CVDs, Alzheimer’s diseases, neurovascular diseases, and endocrine diseases from an immunological perspective. Also, exploration of the key factors and novel pathways involved in this dynamic phenomenon is encouraged. Studies of different levels from cells to animal models are welcomed to address the conceptual framework of disease progression. By discussing about modulating inflammageing, we aim to find promising strategies not only to prevent age-related diseases but also to slow the decline of health that occurs with ageing. With the emerging field of cell therapy and biological drug, discovery of new treatment and prevention of inflammageing and age-related diseases can be achieved.
All scientists and researchers interested in this Research Topic are invited to submit their work in the form of Original Research, Review, and Mini-Review articles, offering new insights within the inflamageing perspective. We welcome manuscripts focusing on, but not limited to, the following sub-topics:
• Articles covering the clinical and research fields in age-related diseases, with a focus on emerging issues and treatments in inflammageing from an immunological perspective.
• Molecular and cellular insights into the mechanisms underlying the progress of inflammation in aging.
• Immunological aspects of degenerative diseases from an inflammaging perspective including, but not limited to: Cancer, CVDs, Alzheimer’s diseases, Neurovascular diseases, and Endocrine diseases.
• Novel treatments and drug discovery of modulating inflammageing.
Keywords: Aging, Cellular senescence, Inflammation, degenerative diseases
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
