Three-dimensional (3D) bioprinting is driving major innovations in tissue engineering and regenerative medicine, in which bioinks consisting of cells and/or biomaterials are printed into complex 3D functional constructs to mimic living tissues and organs using various additive manufacturing approaches. Such engineered tissues and organs are envisioned to be used for the replacement of damaged or injured human tissues and organs, providing a promising solution to the challenge of tissue and organ donor shortage. The typical bioprinting process of 3D tissues and organs are composed of three key steps: 3D bioprinting of cellular constructs, tissue fusion, and tissue maturation. This highly interdisciplinary topic requires integration of manufacturing, materials science, biology, and biomedical engineering. The associated challenges and complexities include biomaterial selection, interaction between cells and extracellular matrix, manufacturing challenges related to the printability of bioinks and sensitivities of living cells, and design and optimization of tissue and organ constructions, to name a few.
This special issue will focus on the cutting-edge research advances in the area of 3D bioprinting of tissue-engineered scaffolds and organs. The resulting understanding will couple the manufacturing and materials science with biomedical applications for more efficient and effective fabrication of 3D living tissues and organs.
Specific topics/themes of interest include, but are not limited to:
-Bioinks and biomaterials: new material development and printability investigation.
-Modeling and analysis of biomanufacturing process.
-Innovation of new 3D bioprinting or biomanufacturing approaches.
-Engineering 2D/3D cellular microenvironments.
-Design, fabrication and characterization of 3D tissue-engineered devices and scaffolds.
-3D bioprinting of complex tissues and organs.
-Bioreactor systems for tissue engineering.
-Cell-biomaterial interaction: cell encapsulation, cell migration, aggregation, and distribution.
-Tissue ingrowth and functionality.
Three-dimensional (3D) bioprinting is driving major innovations in tissue engineering and regenerative medicine, in which bioinks consisting of cells and/or biomaterials are printed into complex 3D functional constructs to mimic living tissues and organs using various additive manufacturing approaches. Such engineered tissues and organs are envisioned to be used for the replacement of damaged or injured human tissues and organs, providing a promising solution to the challenge of tissue and organ donor shortage. The typical bioprinting process of 3D tissues and organs are composed of three key steps: 3D bioprinting of cellular constructs, tissue fusion, and tissue maturation. This highly interdisciplinary topic requires integration of manufacturing, materials science, biology, and biomedical engineering. The associated challenges and complexities include biomaterial selection, interaction between cells and extracellular matrix, manufacturing challenges related to the printability of bioinks and sensitivities of living cells, and design and optimization of tissue and organ constructions, to name a few.
This special issue will focus on the cutting-edge research advances in the area of 3D bioprinting of tissue-engineered scaffolds and organs. The resulting understanding will couple the manufacturing and materials science with biomedical applications for more efficient and effective fabrication of 3D living tissues and organs.
Specific topics/themes of interest include, but are not limited to:
-Bioinks and biomaterials: new material development and printability investigation.
-Modeling and analysis of biomanufacturing process.
-Innovation of new 3D bioprinting or biomanufacturing approaches.
-Engineering 2D/3D cellular microenvironments.
-Design, fabrication and characterization of 3D tissue-engineered devices and scaffolds.
-3D bioprinting of complex tissues and organs.
-Bioreactor systems for tissue engineering.
-Cell-biomaterial interaction: cell encapsulation, cell migration, aggregation, and distribution.
-Tissue ingrowth and functionality.
