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Cell Biology of Salmonella

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The bacterial species Salmonella enterica includes over two thousand serovars that are pathogenic to vertebrates. The range of diseases caused by Salmonella enterica serovars in humans spans from self-limiting infections of the gastrointestinal tract to a life threatening systemic disease, known as typhoid ...

The bacterial species Salmonella enterica includes over two thousand serovars that are pathogenic to vertebrates. The range of diseases caused by Salmonella enterica serovars in humans spans from self-limiting infections of the gastrointestinal tract to a life threatening systemic disease, known as typhoid fever. Besides its medical importance, Salmonella enterica is also a powerful tool for dissecting host-pathogen interactions. Salmonella enterica can colonize many different host cell types, including epithelial cells, fibroblasts and macrophages, and more than two decades of intense research into the cell biology of the Salmonella-host interface have identified many sophisticated strategies of interaction with its host.

Salmonella enterica actively invades non-phagocytic cells and establishes a specialized compartment, termed the Salmonella-containing vacuole. Two type III secretion systems deliver bacterial proteins into host cells and are central for cell invasion and intracellular replication. Salmonella enterica also resides within macrophages, a niche that permits them to establish a systemic infection. We welcome high quality original research articles, as well as review articles, on the cell biology of Salmonella enterica infections in this Research Topic.


Keywords: Salmonella enterica, intracellular pathogen, vacuole, trafficking, epithelial cells, macrophages, type III secretion, host-pathogen interactions


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