Research Topic

Cancer Metabolism: Current Knowledge and Perspectives

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Intrinsic and extrinsic molecular mechanisms converge to alter the cellular metabolism, and provide support for the three basic needs of dividing cells: increased biosynthesis of macromolecules, quick ATP generation and constricted maintenance of appropriate cellular redox status. To meet these needs, cancer ...

Intrinsic and extrinsic molecular mechanisms converge to alter the cellular metabolism, and provide support for the three basic needs of dividing cells: increased biosynthesis of macromolecules, quick ATP generation and constricted maintenance of appropriate cellular redox status. To meet these needs, cancer cells acquire adjustments to the metabolism of all four main classes of macromolecules: carbohydrates, proteins, lipids and nucleic acids. The initial recognition that cancer cells exhibit atypical metabolic characteristics can be traced to the pioneering work of Otto Warburg over the first half of the twentieth century. Nowadays, cancer metabolism is one of the emerging hot topics in cancer research, aiming to elucidate the metabolic needs of cancer cells to identify new therapies. Although, it has been well known that tumor cells undergo considerable metabolic reprogramming to survive and proliferate within the hostile environment and limited nutrient supply, the metabolic profile of invasive and disseminated tumor cells is poorly understood. The advent of new experimental models has helped us to unveil how the metabolic status of phenotypically invasive cancer cells may modulate the tumor aggressiveness. Several early reports contributing to this topic have already been published. These findings besides contributing to a better understanding of disease pathogenesis will generate valuable information that might be used for future diagnostic and therapeutic purposes. This Research Topic is intended to present and discuss all the aspects of the dynamic metabolic transformation in cancer cells by research articles, mini-reviews and reviews.

Potential topics include, but are not limited to:
-Glucose metabolism in cancer cells;
-Lipid metabolism and cancer progression;
-Glycoconjugates metabolism and cancer progression;
-Metabolic reprogramming and cancer stem cells;
-Hypoxia and metabolic reprogramming in cancer;
-Metabolic reprogramming in drug-resistant cancer cells;
-Drugs that target cancer cell metabolism and invasiveness


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