About this Research Topic
Extracellular vesicles (EVs) are small membranous structures released by cells that play important roles in cell-to-cell communication and the transport of various biomolecules. In the context of heart failure, EVs have been found to be involved in several pathological processes. One of the key roles of EVs in heart failure is their contribution to cardiac remodeling. EVs released by cardiac cells, such as cardiomyocytes and fibroblasts, contain various signaling molecules, metabolites and microRNAs that can affect the behavior of other cells in the heart, including immune cells and endothelial cells. These EVs can promote fibrosis, inflammation, and apoptosis, all of which can contribute to the progression of heart failure. In addition, EVs released by circulating cells, such as platelets and leukocytes, can also play a role in heart failure. These EVs can activate endothelial cells, promote inflammation, and contribute to thrombosis, all of which can impair cardiac function.
The main aim of this Research Topic is to better understand the complex interplay between immune cells, metabolic pathways, EVs and microRNA in the context of heart failure, which could lead to the development of new therapies and prevention strategies for this debilitating disease
We welcome the following article types: Original Research, Brief Research Report, Case Report, Clinical Trial, General Commentary, Hypothesis & Theory, Methods, Perspective, Review, Mini Review, Opinion, Study Protocol, and Systematic Review.
We welcome papers focusing on, but not limited to the following themes:
- Immunometabolism and heart failure
- Metabolic basis of trained immunity in cardiovascular diseases
- Extracellular vesicles (EVs) and cardiovascular diseases
- Non-coding RNA, RNA binding proteins and the failing heart
- Cellular crosstalk in cardiovascular diseases
Keywords: Immunometabolism, Heart failure, Metabolic basis of Trained immunity, Extracellular vesicles (EVs), Cardiovascular diseases, Non-coding RNA, RNA binding proteins, Cellular crosstalk
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.