Trace elements and minerals are important for human health by the fact that both deficiency and excess cause numerous metabolic abnormalities such as diabetes mellitus, dyslipidemia, and chronic liver injuries. Trace elements and minerals, including iron, zinc, copper, magnesium, manganese, chromium, molybdenum, selenium, and nickel, etc., have critical roles as both structural and catalytic cofactors for an estimated one-third of the proteome, representing a major contributor to the maintenance of cellular homeostasis. Although current research efforts are exploring the scope of trace element binding proteins and transport systems for the maintenance of cellular homeostasis, a broad spectrum of trace elements, trace element derivates, and trace element based compounds targeting proteins and/or DNA is still in their infancy stage and further research work is needed.
Research on the distribution, dynamics, metabolism, and mechanisms of trace elements and minerals in human diseases, especially metabolic disorders, is still very limited. To deepen our understanding of these nutrients on metabolic disorders and find viable alternatives or complementary strategies to pharmaceutical drugs, we welcome original and high-quality interdisciplinary research papers linking human diseases and nutrition. Studies significantly advancing fundamental understanding and focusing on the interconnection of multiple spheres will be prioritized.
Sub-themes of the Research Topic include (but are not limited to):
· Bioactivities (immunomodulation, etc.) of trace elements, trace element derivates and trace elements-based compounds in metabolic disorders.
· Biodistribution and metabolism of trace elements and minerals in metabolic disorders.
· Regulatory mechanisms of trace elements and minerals for maintaining energy homeostasis and cellular metabolism.
· Interactions and mechanisms of trace elements and minerals with their binding or regulatory metabolites/proteins/peptides in metabolic disorders.
· New nutritional and therapeutic strategies based on trace elements, trace element derivates and trace elements-based compounds in metabolic disorders.
Trace elements and minerals are important for human health by the fact that both deficiency and excess cause numerous metabolic abnormalities such as diabetes mellitus, dyslipidemia, and chronic liver injuries. Trace elements and minerals, including iron, zinc, copper, magnesium, manganese, chromium, molybdenum, selenium, and nickel, etc., have critical roles as both structural and catalytic cofactors for an estimated one-third of the proteome, representing a major contributor to the maintenance of cellular homeostasis. Although current research efforts are exploring the scope of trace element binding proteins and transport systems for the maintenance of cellular homeostasis, a broad spectrum of trace elements, trace element derivates, and trace element based compounds targeting proteins and/or DNA is still in their infancy stage and further research work is needed.
Research on the distribution, dynamics, metabolism, and mechanisms of trace elements and minerals in human diseases, especially metabolic disorders, is still very limited. To deepen our understanding of these nutrients on metabolic disorders and find viable alternatives or complementary strategies to pharmaceutical drugs, we welcome original and high-quality interdisciplinary research papers linking human diseases and nutrition. Studies significantly advancing fundamental understanding and focusing on the interconnection of multiple spheres will be prioritized.
Sub-themes of the Research Topic include (but are not limited to):
· Bioactivities (immunomodulation, etc.) of trace elements, trace element derivates and trace elements-based compounds in metabolic disorders.
· Biodistribution and metabolism of trace elements and minerals in metabolic disorders.
· Regulatory mechanisms of trace elements and minerals for maintaining energy homeostasis and cellular metabolism.
· Interactions and mechanisms of trace elements and minerals with their binding or regulatory metabolites/proteins/peptides in metabolic disorders.
· New nutritional and therapeutic strategies based on trace elements, trace element derivates and trace elements-based compounds in metabolic disorders.