Biocompatible nanocarriers provide an updated guide to the diverse range of biomedical applications of nanocarriers. From biosensing and imaging to tissue engineering, cancer therapy, brain tumors, neurodegenerative disorders, brain drug delivery, as well as other chronic disease therapy. Across the biomedical disciplines, there is an ongoing search for biomaterials that are biodegradable, modifiable, structurally sound, and versatile. Various type of nanocarriers like organic and inorganic-derived nanomaterials possesses a range of properties. This makes them ideal for a variety of biomedical applications, such as controllable geometry, tunable nanoporous structure, large pore volume/high specific surface area, and versatile surface chemistry. Biomaterials design for the delivery of nutraceuticals as well as its use in food safety, food processing, food quality, food packaging, and food labeling is the major challenging task for formulation scientists to achieve targeted drug delivery with the optimum therapeutic benefit of the payload. As there has been a great deal of significant progress over the years to propel nanotechnology for the rational design of biomaterials and drug delivery carriers. It is challenging for the researchers to get a compiled literature of such biomaterials in all aspects from laboratory scale to their commercialization.
The main goals of this Research Topic are focused on biocompatible nanomaterials to reduce toxicity, reduce adverse effects in the gastrointestinal tract by biodegradability, protection, and delivery of bioactive ingredients to enhance the immune response. A variety of disorders, affecting the central nervous system, including diabetes, obesity, gastrointestinal issues, ophthalmic conditions, and cancer, are treated and prevented with the help of nutraceuticals. The human body receives the necessary quantity of nutrition from nutrient-rich foods through diet, but because the majority of the nutrients' bioactive agents are extremely lipophilic and have low aqueous solubility, their dissolution and oral bioavailability are poor. Moreover, the nutraceuticals like quercetin, vitamin C, vitamin B12, carotenoids, anthocyanins, curcumin, and others have drawbacks such as low solubility, chemical instability, a bitter flavor, and a disagreeable odor. Nanotechnology-based nutrient delivery systems can be used to improve oral bioavailability by increasing nutraceutical stability in GIT, increasing nutraceutical solubility in intestinal fluids, and reducing first-pass metabolism in the gut and liver. There are various nanostructures, including starch nanoparticles, starch nanocrystals, starch nanofibers, and even nano-helical amylose structures, that provide many benefits. It can easily cross the blood-brain barrier (BBB) leading to overcoming the limitations of conventional therapeutics and finally improving the therapeutic benefits of loaded nutraceuticals. Yet, the aging process has an impact on a variety of bodily processes. Age-related changes in the cellular, molecular, and physiological functions of tissues and organs can also affect how medications enter, distribute, and are eliminated from the body, even if many of the effects of aging can currently be postponed or decreased. Hence, if we want to produce more age-appropriate treatments, it is important to take into account the evolving profile of drug delivery hurdles. It may be necessary to develop oral delivery systems that enable greater retention at absorption sites due to changes in the drug breakdown and absorption in older patients in order to improve drug delivery. In order to deliver bioactive molecules effectively, this Research Topic will compile the characteristics and uses of a variety of nanocarriers, including dendrimers in organic nanoparticles, polymeric nanoparticles, micelles, liposomes, niosomes, solid lipid nanocarriers, and nanostructured lipid carriers.
This current Research Topic collects both research and review articles that are encouraged to be submitted. The specific themes we would like contributors to address are, but are not limited to:
•Phyto-nutraceutical in therapeutics and carrier for drug delivery
•Nanocarrier-based targeted approaches in Antiaging
•Nanocarrier-based targeted approaches in cancer
•Biodegradable, biocompatible carriers for nutraceuticals drug and gene delivery
•Polymeric nanoparticles for the treatment and diagnosis of cardiovascular diseases, Neurodegenerative disease
•Curcumin-loaded biocompatible nanoparticles for cancer drug delivery
•Polypeptides, nucleic acids based drug delivery strategies
•Nanocapsules, Liposomes, Polymersomes, Micelles and Nanoemulsions based for taragted delivery
Keywords:
nanocarriers, surface modification, nutrient drug delivery, nutraceuticals
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Biocompatible nanocarriers provide an updated guide to the diverse range of biomedical applications of nanocarriers. From biosensing and imaging to tissue engineering, cancer therapy, brain tumors, neurodegenerative disorders, brain drug delivery, as well as other chronic disease therapy. Across the biomedical disciplines, there is an ongoing search for biomaterials that are biodegradable, modifiable, structurally sound, and versatile. Various type of nanocarriers like organic and inorganic-derived nanomaterials possesses a range of properties. This makes them ideal for a variety of biomedical applications, such as controllable geometry, tunable nanoporous structure, large pore volume/high specific surface area, and versatile surface chemistry. Biomaterials design for the delivery of nutraceuticals as well as its use in food safety, food processing, food quality, food packaging, and food labeling is the major challenging task for formulation scientists to achieve targeted drug delivery with the optimum therapeutic benefit of the payload. As there has been a great deal of significant progress over the years to propel nanotechnology for the rational design of biomaterials and drug delivery carriers. It is challenging for the researchers to get a compiled literature of such biomaterials in all aspects from laboratory scale to their commercialization.
The main goals of this Research Topic are focused on biocompatible nanomaterials to reduce toxicity, reduce adverse effects in the gastrointestinal tract by biodegradability, protection, and delivery of bioactive ingredients to enhance the immune response. A variety of disorders, affecting the central nervous system, including diabetes, obesity, gastrointestinal issues, ophthalmic conditions, and cancer, are treated and prevented with the help of nutraceuticals. The human body receives the necessary quantity of nutrition from nutrient-rich foods through diet, but because the majority of the nutrients' bioactive agents are extremely lipophilic and have low aqueous solubility, their dissolution and oral bioavailability are poor. Moreover, the nutraceuticals like quercetin, vitamin C, vitamin B12, carotenoids, anthocyanins, curcumin, and others have drawbacks such as low solubility, chemical instability, a bitter flavor, and a disagreeable odor. Nanotechnology-based nutrient delivery systems can be used to improve oral bioavailability by increasing nutraceutical stability in GIT, increasing nutraceutical solubility in intestinal fluids, and reducing first-pass metabolism in the gut and liver. There are various nanostructures, including starch nanoparticles, starch nanocrystals, starch nanofibers, and even nano-helical amylose structures, that provide many benefits. It can easily cross the blood-brain barrier (BBB) leading to overcoming the limitations of conventional therapeutics and finally improving the therapeutic benefits of loaded nutraceuticals. Yet, the aging process has an impact on a variety of bodily processes. Age-related changes in the cellular, molecular, and physiological functions of tissues and organs can also affect how medications enter, distribute, and are eliminated from the body, even if many of the effects of aging can currently be postponed or decreased. Hence, if we want to produce more age-appropriate treatments, it is important to take into account the evolving profile of drug delivery hurdles. It may be necessary to develop oral delivery systems that enable greater retention at absorption sites due to changes in the drug breakdown and absorption in older patients in order to improve drug delivery. In order to deliver bioactive molecules effectively, this Research Topic will compile the characteristics and uses of a variety of nanocarriers, including dendrimers in organic nanoparticles, polymeric nanoparticles, micelles, liposomes, niosomes, solid lipid nanocarriers, and nanostructured lipid carriers.
This current Research Topic collects both research and review articles that are encouraged to be submitted. The specific themes we would like contributors to address are, but are not limited to:
•Phyto-nutraceutical in therapeutics and carrier for drug delivery
•Nanocarrier-based targeted approaches in Antiaging
•Nanocarrier-based targeted approaches in cancer
•Biodegradable, biocompatible carriers for nutraceuticals drug and gene delivery
•Polymeric nanoparticles for the treatment and diagnosis of cardiovascular diseases, Neurodegenerative disease
•Curcumin-loaded biocompatible nanoparticles for cancer drug delivery
•Polypeptides, nucleic acids based drug delivery strategies
•Nanocapsules, Liposomes, Polymersomes, Micelles and Nanoemulsions based for taragted delivery
Keywords:
nanocarriers, surface modification, nutrient drug delivery, nutraceuticals
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.