From Structure to Signalosomes: New Perspectives About Membrane Receptors and Channels

114.8K

views

115

authors

16

articles

From Structure to Signalosomes: New Perspectives About Membrane Receptors and Channels

114.8K

views

115

authors

16

articles

Editorial

22 May 2019

Editorial: From Structure to Signalsomes: New Perspectives About Membrane Receptors and Channels

Yi Ma

,

Kai He

and

Gerald A. Berkowitz

2,861 views

3 citations

Editors

3

Gerald Alan Berkowitz

University of Connecticut

Lanzhou University

University of Connecticut

Impact

About

Over the last few years, breakthrough work in a number of areas has increased our understanding of how membrane receptors and cell transport proteins (such as ion channels) function. Many aspects of the post-translational modifications that regulate these proteins have also been delineated. Areas of new knowledge include, but are not limited to the following research themes. (A) Molecular structure related to function. (B) Trafficking (delivery and removal) of receptors as a component of signaling cascades. (C) Presence of receptors, co-receptors, and ion channels in multi-enzyme protein complexes acting in an integrated fashion. These signaling complexes facilitate localized generation of regulatory mechanisms and secondary cell signals to activate downstream response cascades. (D) Knowledge about non-cell autonomous peptide and hormone receptors and how the ligand-receptor interaction leads to downstream regulation of cell function. (E) Signaling cascades involving kinase relays.

New information about these aspects of plant cell membrane transport and trafficking provides a fuller understanding of the molecular mechanisms that regulate plant growth, development, signal response, and resistance to external stresses. A Research Topic that covers membrane receptors and channels that is open to contributions from aforementioned research areas (and related topics) has the potential to provide readers with understanding of transport and trafficking with new and more nuanced perspectives.

Over the last few years, breakthrough work in a number of areas has increased our understanding of how membrane receptors and cell transport proteins (such as ion channels) function. Many aspects of the post-translational modifications that regulate these proteins have also been delineated. Areas of new knowledge include, but are not limited to the following research themes. (A) Molecular structure related to function. (B) Trafficking (delivery and removal) of receptors as a component of signaling cascades. (C) Presence of receptors, co-receptors, and ion channels in multi-enzyme protein complexes acting in an integrated fashion. These signaling complexes facilitate localized generation of regulatory mechanisms and secondary cell signals to activate downstream response cascades. (D) Knowledge about non-cell autonomous peptide and hormone receptors and how the ligand-receptor interaction leads to downstream regulation of cell function. (E) Signaling cascades involving kinase relays.

New information about these aspects of plant cell membrane transport and trafficking provides a fuller understanding of the molecular mechanisms that regulate plant growth, development, signal response, and resistance to external stresses. A Research Topic that covers membrane receptors and channels that is open to contributions from aforementioned research areas (and related topics) has the potential to provide readers with understanding of transport and trafficking with new and more nuanced perspectives.

Download ebook

Share

Editors

Gerald Alan Berkowitz

University of Connecticut

Lanzhou University

University of Connecticut

Impact

114,795 Total views

80,533 Article views

31,159 Article downloads

3,103 Topic views

Published In

Journal Thumbnail

Frontiers in Plant Science

Plant Membrane Traffic and Transport

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic