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From Structure to Signalsomes: New perspectives about membrane receptors and channels

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Over the last few years, breakthrough work in a number of areas has increased our understanding of how membrane receptors and cell transport proteins (such as ion channels) function. Many aspects of the post-translational modifications that regulate these proteins have also been delineated. Areas of new ...

Over the last few years, breakthrough work in a number of areas has increased our understanding of how membrane receptors and cell transport proteins (such as ion channels) function. Many aspects of the post-translational modifications that regulate these proteins have also been delineated. Areas of new knowledge include, but are not limited to the following research themes. (A) Molecular structure related to function. (B) Trafficking (delivery and removal) of receptors as a component of signaling cascades. (C) Presence of receptors, co-receptors, and ion channels in multi-enzyme protein complexes acting in an integrated fashion. These signaling complexes facilitate localized generation of regulatory mechanisms and secondary cell signals to activate downstream response cascades. (D) Knowledge about non-cell autonomous peptide and hormone receptors and how the ligand-receptor interaction leads to downstream regulation of cell function. (E) Signaling cascades involving kinase relays.

New information about these aspects of plant cell membrane transport and trafficking provides a fuller understanding of the molecular mechanisms that regulate plant growth, development, signal response, and resistance to external stresses. A Research Topic that covers membrane receptors and channels that is open to contributions from aforementioned research areas (and related topics) has the potential to provide readers with understanding of transport and trafficking with new and more nuanced perspectives.


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