About this Research Topic
Invertebrate genetic model systems, such as roundworms, and fruit flies, are ideal for longevity research due to their short life cycle, advanced genetic tool kit, large quantity, and low cost. Invertebrate models have contributed to many discoveries in aging research including those on mitochondrial stress, insulin-like signaling, heat shock, hypoxia response, and maintenance of tissue homeostasis. These invertebrate animal studies suggest that pathways underlying improved longevity act through cell non-autonomous mechanisms. Furthermore, emerging invertebrate model organisms such as hydra and planarians provide new platforms for understanding how stem cell renewal and tissue repair influence longevity.
In summary, longevity research using invertebrate models is an exciting area. It has a great potential to improve our understanding of the aging process and creates opportunities for therapeutic advances to improve healthy ageing.
In this research topic we aim to demonstrate biological mechanisms by which genetic and various environmental conditions play critical roles in modulating physiology and aging. Potential areas of interests include, but are not limited to:
· How does the perception of a changing environment contribute to physiology and aging
· Emerging invertebrate model organisms for longevity and aging research
· Cell non-autonomous mechanisms underlying longevity and aging
· The role of gene-environment interaction in health and aging
· How do health critical behaviors promote longevity
We welcome submissions of diverse article types to this collection,including reviews, mini-reviews, and original research papers. See the Invertebrate Physiology section for a full list of the types of articles that can be considered.
Keywords: Aging, Invertebrate models, tissue repair, stem cell
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.