There has been increasing evidence in the past decades showing inflammation is closely associated with many chronic health conditions including diabetes, metabolic syndrome, cardiovascular disease, cancer, rheumatoid arthritis, inflammatory bowel disease, asthma, and chronic obstructive lung disease. Inflammation is a normal biological defense against infection and tissue damage. Under normal circumstances, it quickly ends after the infection or injurious agents are removed. However, in many chronic conditions, the inflammatory response continues and leads to significant tissue/organ damage. Dysregulation of inflammatory response contributes broadly to the development of those chronic conditions. Despite the recognition of the importance of inflammatory dysregulation in chronic illnesses, the mechanisms underlying the inflammatory regulation of these disorders are not fully understood.

This Research Topic issue will cover a wide range of subjects in inflammatory regulation in chronic diseases. Scientists in both clinical and basic sciences are expected to participate in this Research Topic issue. Potential topics include, but are not limited to:
 Mechanism regulating inflammation in chronic diseases
 Inflammatory markers in the diagnosis of chronic disorders
 Clinical immunology in inflammatory diseases
 The role of acute phase proteins and cytokines in inflammatory regulation
 Relationships between inflammation and metabolism
 Inflammation in organs/tissues (fat, liver, muscle, pancreas, etc)
 Anti-inflammatory agents in chronic illnesses
 The role of different immune populations in modulating inflammatory processes
 Immunotherapy in cardiovascular disease and other chronic conditions
 Role of immune cells in the development and progression of cardiometabolic disease
 Inflammatory regulation in autoimmune diseases

Keywords: Inflammation; immunity; chronic disease; inflammatory regulation; cytokines

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.