Tuberculosis (TB) threatens global public health and remains one of the major infectious diseases worldwide. Effective detection and treatment of both drug-sensitive and drug-resistant TB are key challenges in the fight against TB. Currently, only about 50% of the WHO target TB cases are detected and only 30-40% of drug-resistant TB cases are recognized. Treatment success rates are approximately 85% for drug-sensitive TB and drop to only ~60% for multi-drug resistant TB (MDR-TB) on average worldwide. Early detection of TB cases is the first step to providing patients with appropriate treatment. Recognizing drug-resistant TB is more challenging and requires quick and accurate drug susceptibility test (DST) methods. In addition to improved diagnosis and DST, the discovery of new drug targets is crucial for TB control.
This Research Topic focusses on TB and drug-resistance diagnosis, and drug target discovery. It aims to explore novel TB diagnosis methods to quickly find TB cases and recognize drug-resistance. DST for anti-TB drugs is also essential to guide the further diagnosis of drug-resistant TB, how to evaluate and compare them, and establish new DST methods to further guide clinics to use rationally is the other purpose under this topic. At the same time, this Research Topic aims to explore new drug resistance mechanisms and tools to study drug resistance. Finally, it explores new drug targets and tools to study them.
In this Research Topic, we welcome both original articles and review articles on the following subtopics:
1. Novel diagnostic tools for TB, drug-resistant TB or latent TB infection
2. Evaluation and application of diagnostic tools for TB, drug-resistant TB or latent TB infection
3. Resistance mechanism to TB drugs, and comparison and application of different DST methods for drug-resistant TB
4. TB drug target discovery
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Tuberculosis (TB) threatens global public health and remains one of the major infectious diseases worldwide. Effective detection and treatment of both drug-sensitive and drug-resistant TB are key challenges in the fight against TB. Currently, only about 50% of the WHO target TB cases are detected and only 30-40% of drug-resistant TB cases are recognized. Treatment success rates are approximately 85% for drug-sensitive TB and drop to only ~60% for multi-drug resistant TB (MDR-TB) on average worldwide. Early detection of TB cases is the first step to providing patients with appropriate treatment. Recognizing drug-resistant TB is more challenging and requires quick and accurate drug susceptibility test (DST) methods. In addition to improved diagnosis and DST, the discovery of new drug targets is crucial for TB control.
This Research Topic focusses on TB and drug-resistance diagnosis, and drug target discovery. It aims to explore novel TB diagnosis methods to quickly find TB cases and recognize drug-resistance. DST for anti-TB drugs is also essential to guide the further diagnosis of drug-resistant TB, how to evaluate and compare them, and establish new DST methods to further guide clinics to use rationally is the other purpose under this topic. At the same time, this Research Topic aims to explore new drug resistance mechanisms and tools to study drug resistance. Finally, it explores new drug targets and tools to study them.
In this Research Topic, we welcome both original articles and review articles on the following subtopics:
1. Novel diagnostic tools for TB, drug-resistant TB or latent TB infection
2. Evaluation and application of diagnostic tools for TB, drug-resistant TB or latent TB infection
3. Resistance mechanism to TB drugs, and comparison and application of different DST methods for drug-resistant TB
4. TB drug target discovery
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