Damage-associated molecular patterns (DAMPs) is a term for endogenous ‘danger’ molecules that are released by cells due to cellular stress form either becoming damaged or dying, such as secretory protein factors and intracellular protein molecules. Thereby inciting a potent innate immune response by their interaction with pattern recognition receptors (PRRs) on the cell surface. Through this inducing of an inflammatory body response, DAMPs are being linked, with ever increasing evidence, as a key player in the pathogenesis of human diseases such as autoimmune disorders, cardiovascular disease, neurodegeneration and cancer.
However, with increasing research into DAMPs and their relationships to multiple diseases, they have also revealed themselves to be a valuable biomarker. Such as an increase in S100A8/A9 being associated with early stage osteoarthritis, or heat shock proteins and adenosine triphosphate in cancer providing a useful prognostic factor for patients.
For this Research Topic, we hope to elucidate cell death and its links to DAMPs and their potential use in therapeutics. We are also looking for, but not limited to:
- DAMPs and autophagy and their link to tumor cell death, immunity and anti-inflammatory response
- Necrosis leading to release of DAMPs providing pro-inflammatory response
- DAMPs and their potential use as biomarkers for inflammatory diseases
- DAMPs as therapeutic target, for example in for CAR-T related toxicities
Keywords:
Damage-Associated Molecular Patterns, DAMPs, Immune Response, Autoimmune Disorders, Cardiovascular Disease, Neurodegeneration, Cancer
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Damage-associated molecular patterns (DAMPs) is a term for endogenous ‘danger’ molecules that are released by cells due to cellular stress form either becoming damaged or dying, such as secretory protein factors and intracellular protein molecules. Thereby inciting a potent innate immune response by their interaction with pattern recognition receptors (PRRs) on the cell surface. Through this inducing of an inflammatory body response, DAMPs are being linked, with ever increasing evidence, as a key player in the pathogenesis of human diseases such as autoimmune disorders, cardiovascular disease, neurodegeneration and cancer.
However, with increasing research into DAMPs and their relationships to multiple diseases, they have also revealed themselves to be a valuable biomarker. Such as an increase in S100A8/A9 being associated with early stage osteoarthritis, or heat shock proteins and adenosine triphosphate in cancer providing a useful prognostic factor for patients.
For this Research Topic, we hope to elucidate cell death and its links to DAMPs and their potential use in therapeutics. We are also looking for, but not limited to:
- DAMPs and autophagy and their link to tumor cell death, immunity and anti-inflammatory response
- Necrosis leading to release of DAMPs providing pro-inflammatory response
- DAMPs and their potential use as biomarkers for inflammatory diseases
- DAMPs as therapeutic target, for example in for CAR-T related toxicities
Keywords:
Damage-Associated Molecular Patterns, DAMPs, Immune Response, Autoimmune Disorders, Cardiovascular Disease, Neurodegeneration, Cancer
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.