About this Research Topic
The research breakthrough of generating induced pluripotent stem cells (iPSCs) from differentiated cells and using them to generate different cell types has propelled many areas of research further towards novel therapeutic strategies. In neurodegeneration, the advantages are mainly focused on replacing lost neurons or protecting remaining neurons in progressive disease. Additionally, the use of iPSCs generated from patient cells has the unique potential to recapitulate patient-specific disease pathology in induced-neurons. This is extremely valuable in the context of disease modeling to understand the mechanisms occurring in neurons prior to degeneration.
In this Research Topic we welcome papers (reviews and original research) describing the use of stem cells either in disease modeling or as a therapy in neurodegeneration. This includes, but is not limited to, comparisons of protocols for cell type-specific conversion, characterization of obtained neurons, therapeutic use of stem cells to replace neurons or create a protective environment, and the use of patient-derived cells for increased understanding of disease mechanisms in neurodegeneration.
Keywords: iPSCs, disease modeling, embryonic stem cells, iNs, stem cell therapy
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