About this Research Topic
Diabetes mellitus (DM), as a major health problem, has been highly prevalent across the globe. It is increasingly apparent that not only a cure for the current worldwide diabetes epidemic is required, but also a cure for its major complications, including heart disease, chronic kidney disease, and nerve damage. In addition, other problems with feet, oral health, vision, hearing, reproduction, and mental health need to be explored as well. Understanding the underlying mechanisms of these diabetic complications would be helpful to prevent or delay the occurrence of complications and to improve the overall health condition of people with DM. Unfortunately, current therapies only slow down disease deterioration of most prevalent diabetic complications. Indeed, whether the mechanisms in diabetic complications are protective or pathological remains not fully defined, based on the impacts during the underlying disease process.
Thus, we welcome academic articles that can provide the latest insights into the pathophysiology of diabetes-related complications. These submissions range from uncovering the intracellular signaling pathways with the development of diabetic complications, to exploring the possible role of genetic issues, metabolic regulation, and inflammation mechanisms.
We welcome high-quality Original Research and Review articles that contribute to the mechanism investigation of a range of diabetic complications, including but not limited to:
• Microvascular damage-related diseases in diabetic patients, such as neuropathy, nephropathy, and retinopathy;
• Foot damage and skin problems in diabetes;
• Reproductive disorder in diabetic women;
• The relationship between diabetes and the development of Alzheimer's disease, depression, and cognitive impairment.
In this continued Volume II, we are looking forward to seeing many more academic articles on DM-related heart disease, a reproductive disorder in diabetic women or the relationship between diabetes and the development of Alzheimer’s disease, etc.
Also, Methods articles that introduce novel experimental methods or animal models that contribute to understanding the formation and progress of diabetic complications are continually welcome. Opinions or Perspectives regarding the implications of new research on the treatment of diabetic complications are encouraged too.
Keywords: Diabetes, Complication, Pathophysiology, Mechanism, Therapeutic strategies
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.