About this Research Topic
The goal of this Research Topic is to provide a comprehensive overview on the significance of microbiomes present in different body niches in the context of varied immunocompromised hosts’ profiles. Although the data on PID appear more preliminary, there is still an exciting issue of “what shapes what?”- either the immune system shapes the microbiome or vice versa. This question remains valid for SID as well. However, as in high income countries SID are in majority iatrogenic, other question emerges about the influence of the microbiome on the clinical outcome. Both these can potentially be addressed by multi-omic approach which integrates metagenomics with proteomic or even more likely, metabolomic data. Nevertheless direct translation of even well-integrated multi-omic data remains challenging and the critical input of bioinformaticians will be strongly valued. Therefore, within this Research Topic, we will take the opportunity to get a deeper insight into the current state of the art in terms of microbiome in different immunocompromised hosts . Furthermore, will verify perspectives we can follow and limitations we have to face. Finally, we will identify the most thriving questions.
Following research themes will be addressed:
- diversity of microbiomes in terms of different immunocompromised host profiles including bacterial microbiota, virome and including gut and other niches
- relation between the microbiome, immune and metabolic status of the host in the context of PID and SID
- translation of microbiomic research into practice, identifying prognostic biomarkers with
a special regard to cancer research
- the role of gut microbiome in immunosuppressive drugs metabolism
- bioinformatic platforms used in multi-omic data integration and translation
Original articles, critical review articles and short communications will be expected.
Keywords: microbiome, immunocompromised host, primary immunodeficiency, secondary immunodeficiency
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