About this Research Topic
This Research Topic focuses on the relationship between pyroptosis and endometrial carcinoma. We try to investigate the mechanism of pyroptosis and elucidate the role of ESCRT proteins in reducing pyroptosis and mediating cell membrane repair in endometrial carcinoma. Our goal is to identify possible prognosis of endometrial cancer related to GSDMD or ESCRT and find more efficient and accurate biomarkers on the basis of pyroptosis, thus contributing to the early screening of patients and promoting the development of accurate treatment and immunotherapy. We hope to bring together insightful research and provide new and personalized strategies for the diagnosis, treatment, and prognosis of endometrial cancer in this Research Topic.
● Mechanisms of pyroptosis affecting endometrial carcinoma.
● Pathway of cell membrane remodeling in endometrial carcinoma.
● The relationship and interaction between pyroptosis or proteins negatively regulating pyroptosis and cell membrane remodeling in endometrial carcinoma.
● Interaction between pyroptosis and immune cells or stromal cells during the occurrence and development of endometrial carcinoma.
● Screening for new prognostic markers related to pyroptosis in endometrial carcinoma.
● Identification of potential targets related to pyroptosis in endometrial tumors immunotherapy for individualized and comprehensive treatment.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: pyroptosis, cell death, cell membrane remodeling, endometrial carcinoma, the endosomal sorting complex required for transport
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